Explain the NATURAL HISTORY OF CORONARY ARTERY DISEASES (GAD)?

The natural history of CAD is very important from the preventive point or view. Though the usual manifestations of angina and heart attacks tend to occur at the middle age, numerous studies have shown that the process starts very early in life, even as early as three years of age. Evidence ii-on1 various autopsy studies, animals experiments, and long-term epidemiological studies supports the concept that seed of atherosclerosis is sown in childhood and it has also been shown that coronary risk factors which accelerate the process may also original in the same age group. Post mortem analysis of hearts of young US casualties (mean age 22 years) in the Korean and Vietnam conflicts showed the incidence of coronary Atherosclerosis lesions to be 77 percent and 45 per cent, respectively.

The Bogalusa heart surgery clearly showed a positive correlation between childhood risk factors and coronary artery lesion. More recently, the notion that coronary atherosclerosis begins at a young age was confirmed by an in vivo intravascular ultrasound (IVUS) study appearing in the June 5, 2001 issue of Circulation where one in sixteen's were found to have Atherosclerosis plaque in their coronary arteries. Young Americans who have risk factors for clinical coronary heart disease - in particular high LDL cholesterol levels and obesity - have a high prevalence of advanced Atherosclerosis plaques in their arteries that contain qualities indicating vulnerability to rupture, according to the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group reporting in the July 25, 2000 issue of Circulation.