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Explain Nephrotoxicity
Nephrotoxicity is the major dose-limiting toxicity of amphotericin B deoxycholate; sodium loading with normal saline may prevent or ameliorate it and is generally recommended for patients who can tolerate a fluid load. The nephrotoxicity of amphotericin B may add to the nephrotoxicity of other drugs including cyclosporine (Sandimmune, Neoral), tacrolimus (Prograf) and aminoglycoside antibiotics like gentamicin (Garamycin, and others). Hypo- kalemia and hypomagnesemia are common and are usually due to a mild renal tubular acidosis. Weight loss, malaise, anemia, thrombocytopenia and mild leukopenia can happen. Cardiac toxicity and myopathy have been reported.
Segmentation in Regenerating Annelids Several worms as they grow continue to add new segments at the posterior end. In these, segmentation takes place in a growth zone located
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a) Name three parts of the body where smooth (involuntary or unstriated) muscle may be found. b) In any one of your examples, say what the smooth muscle does.
Calvin cycle electron transport chain glycolysis Kreb's cycle photosystem II.
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