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Explain Nephrotoxicity
Nephrotoxicity is the major dose-limiting toxicity of amphotericin B deoxycholate; sodium loading with normal saline may prevent or ameliorate it and is generally recommended for patients who can tolerate a fluid load. The nephrotoxicity of amphotericin B may add to the nephrotoxicity of other drugs including cyclosporine (Sandimmune, Neoral), tacrolimus (Prograf) and aminoglycoside antibiotics like gentamicin (Garamycin, and others). Hypo- kalemia and hypomagnesemia are common and are usually due to a mild renal tubular acidosis. Weight loss, malaise, anemia, thrombocytopenia and mild leukopenia can happen. Cardiac toxicity and myopathy have been reported.
Assume that the blood volume of a rabbit is 0.5 liters. If the effective dose of the anesthetic urethane is 10 micrograms/mL, calculate the volume of a 25% urethane solution that m
Q. Explain Degradation of Fats? Fats are the esters of glycerol and fatty acids and are called as 'glycerides'. Fats are susceptable to hydrolysis, oxidation and other che
what is r and k selection
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Compared to amphibians what are the two reproductive novelties of beings of the class Reptilia for the survival in dry environments? Compared to amphibians the two major reprod
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