Explain nephrotoxicity, Biology

Assignment Help:

Explain Nephrotoxicity

Nephrotoxicity is the major dose-limiting toxicity of amphotericin B deoxycholate; sodium loading with  normal saline may prevent or ameliorate it and is generally recommended for patients who can tolerate a fluid load. The nephrotoxicity of amphotericin B may add to the nephrotoxicity of other drugs including cyclosporine (Sandimmune, Neoral), tacrolimus  (Prograf)  and aminoglycoside antibiotics like gentamicin (Garamycin, and others). Hypo- kalemia and hypomagnesemia are common and are usually due to a mild renal tubular acidosis. Weight loss, malaise, anemia, thrombocytopenia and mild leukopenia can happen. Cardiac toxicity and myopathy have been reported.

 


Related Discussions:- Explain nephrotoxicity

Bomb calorimeter, Bomb calorimeter is used to determine the calorific value...

Bomb calorimeter is used to determine the calorific value of solid and liquid fuels. Construction          It consists of following parts 1.      Stainless steel bomb:

Factors affects oxygen dissociation curve - Carbon dioxide , Factors affect...

Factors affects oxygen dissociation curve - Carbon dioxide Carbon dioxide lowers the oxygen affinity of haemoglobin even if the pH is kept constant. This effect is due to the

What are the elements that constitute the internal ear, Q. What are the ele...

Q. What are the elements that constitute the internal ear? What are the functions of those structures? In the internal ear there are the semicircular canals and the cochlea. Th

Trypsin, Trypsin Trypsin is secreted by the pancreas in an inactive fo...

Trypsin Trypsin is secreted by the pancreas in an inactive form trypsinogen. It is activated by enterokinase secreted by the glands in the intestinal wall. As trypsin is forme

Describe the terms – cilia, Cilia and flagella share a common structure, wi...

Cilia and flagella share a common structure, with a microtubular core which has a 9+2 organization with nine paired doublets of microtubules surrounding a central pair to form the

Management of symptomatic patients, Q. Management of Symptomatic Patients ...

Q. Management of Symptomatic Patients All symptomatic patients with severe aortic stenosis or even moderately severe aortic stenosis should undergo aortic valve replacement an

How is opening and closing of stomata controlled, How is opening and closin...

How is opening and closing of stomata controlled? Describe a) Why is the length of a food chain in an ecosystem generally limited to 3 - 4 trophic levels? Explain with an examp

Use of gloves as personal protective equipment, Q. Use of Gloves as persona...

Q. Use of Gloves as personal protective equipment? Gloves are task specific. The different types of gloves worn in the dental office are: i) Examination gloves ii) Over o

Plant physiology, application of apical dominace in horticulture and agricu...

application of apical dominace in horticulture and agriculture short notes

What is cytogenetics, What is Cytogenetics? Before the advent of modern...

What is Cytogenetics? Before the advent of modern technology, the American biologists Thomas Hunt Morgan, G.W. Beadle, H. Sturtevant, Barbara McClintock, and others contributed

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd