Explain lipoprotein excess, Biology

Assignment Help:

Explain Lipoprotein (Lp(a) Excess ?

While cholesterol and triglycerides are important lipid risk factors, another lipoprotein factor called Lipoprotein (a) is thought to play a significant role especially in genetic predisposition to coronary artery disease. Lp (a) is a sub fraction of LDL but ten times more atherogenic, and its serum level is genetically determined. Being a dual pathogen influencing both atherosclerotic and thrombotic process, it is considered as a powerful independent risk factor for premature and extensive coronary disease. It is widely believed to be a biological marker for familial CAD, having the same significance as that of a history of premature CAD in the family.

The inherited serum levels of Lp(a) are not influenced by gender, diet, smoking, or other risk factors. The pathological effects of Lp (a) begin at a level of 20-30 mg/dl and are magnified in the presence of high LDL, low HDL or a high TCHDLc ratio, again highlighting the significance of lipid fraction interrelationship. There is a ethnic and genetic variability in the level of Lp(a). Indians have a higher level than other groups or races like Chinese or Japanese.

However there are no data showing that the decrease in Lp(a) levels is associated with a decrease in the incidence of Cardio-vascular or cerebro-vascular disease. The value of the routine screening for, and/or treating Lp(a) excess, is therefore still debatable. Even then Lp(a) levels should probably be taken into account impatient with CAD without established risk factors. The other factors should be rigorously modified or eliminated because, as has been seen, in hypercholesterolemia patients with increased Lp(a) levels, the decrease in LDL cholesterol levels is followed by neutralisation of the atherogenic potential of Lp(a).

 


Related Discussions:- Explain lipoprotein excess

What is knot tying, What is Knot tying Once the suture is satisfactoril...

What is Knot tying Once the suture is satisfactorily placed, it must be secured with a knot. The instrument tie is used most commonly in cutaneous surgery. The square knot is t

Problem of survival among cheetahs, Once quite widespread throughout Asia a...

Once quite widespread throughout Asia and Africa, there has been a large reduction of the cheetah's habitat and numbers though it is still seen in widely separated areas of Africa.

Explain about hydroxyapatite coating, Hydroxyapatite coating Hydroxyapa...

Hydroxyapatite coating Hydroxyapatite coating has been recommended for clinical use. These implants are superior with respect to the degree and rate of fixation in the bone as

Spina bifida cystica, Spina Bifida Cystica There is a protrusion of me...

Spina Bifida Cystica There is a protrusion of meninges and spinal cord a) Meningocele- it is relatively uncommon lesion (4-5 per cent). In this there is protrusion of me

Give three examples of artificial selection, Give three examples of artific...

Give three examples of artificial selection. Include examples of both animals and plants.  Answers will vary, but could include domestic cats, domestic dogs, cattle, sheep, an

Metaphase of karyokinesis, - Nuclear membrane disorganize at the beginning ...

- Nuclear membrane disorganize at the beginning of this phase. - Spindle fibers originate and the kinetochore fibers attach to the kinetochore of homologous chromosomes from eac

Amphibia, describe general characters and classification of amphibia in bri...

describe general characters and classification of amphibia in brief

Homo sapiens, Homo sapiens first appeared in the fossil record between 200,...

Homo sapiens first appeared in the fossil record between 200,000 to 300,000 years ago, The fossils were the Swanscomb man from England and Steinheim man from Germany. a) The Swa

Protein synthesis, Where in eukaryotic cells does mRNA synthesis occur? To ...

Where in eukaryotic cells does mRNA synthesis occur? To where do these molecules migrate?

Coelenterata – General characters and classification., Coelenterata – Gener...

Coelenterata – General characters and classification.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd