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Isobologram is a diagram used to characterize the interactions among jointly administered drugs or the chemicals. The contour of the constant response (that is the isobole), which is compared to the 'line of additivity', that is the line connecting the single drug doses which yield the level of response related with that contour. The interaction is described as the synergistic, additive, or an antagonistic according to whether the isobole is below, or coincident with, or above the line.
Paired availability design is a design which can lessen selection bias in the situations where it is not possible to use random allocation of the subjects to treatments. The desig
Clinical vs. statistical significance : The distinction among results in terms of their possible clinical importance rather than simply in terms of their statistical importance. Wi
a researcher is interested in whether students who attend privte high schools have higher average SAT Scores than students in the general population. a random sample of 90 student
Lagrange Multiplier (LM) test The Null Hypothesis - H0: There is no heteroscedasticity i.e. β 1 = 0 The Alternative Hypothesis - H1: There is heteroscedasticity i.e. β 1
L'Abbe ´ plot is often used in the meta-analysis of the clinical trials where the result is the binary response of it. The event risk (number of events/number of the patients in a
You have probably noticed by now that some of the statements of necessary and sufficient conditions sound more natural than others. For example it seems more natural to express "We
Reasons for screening data Garbage in-garbage out Missing data a. Amount of missing data is less crucial than the pattern of it. If randomly
The initial evaluation of the set of observations to see whether or not they appear to satisfy the hypotheses or assumptions of the methods to be used in their analysis. Techniques
Literature controls : The patients with the disease of interest who have received, in the past, one of two treatments under the investigation, and for whom the results have been pu
Laplace distribution : The probability distribution, f(x), given by the following formula Can be derived as the distribution of the difference of two independent random var
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