Explain Increased Fibrinogen Levels and Other Thrombogenic Factors ?

Thsombogenesis is an important component in the pathological process of atherosclerosis and so it is not surprising that a number of studies have clearly shown the association of increased plasma fibrinogen levels with Cardio-vascular disease and that the reduction of the increased fibrinogen levels in CAD patients could decrease the incidence of cardiac death and ischemic stroke. The substantial variability of plasma fibrinogen levels because of a number of factors including the assay used, socio-economic and metabolic factors, etc., limit the wide application of this coagulation factor as a risk marker in everyday clinical practice.

However it is important to note that smoking cessation, weight loss, regular exercise, moderate alcohol consumption and drugs like fibrates can significantly reduce plasma fibrinogen levels.

Several other factors participating in blood coagulation have been associated with CVD risk, including factor VII levels, plasminogen activator inhibitor - 1 (PAI-1) and increased platelet aggregation. Many randomised controlled trials have shown the beneficial effect of ant platelet agents in the prevention of Cardio-vascular events in patients with established vascular disease.