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Emtricitabine (FTC, Emtriva)
Emtricitabine is the 5-fluorinated derivative of lamivudine. It has same safetyand efficacy, and can be given once daily. It is available alone or in a fixeddose combination with tenofovir (Truvada). Resistance to emtricitabine is conferred by the M184V mutation, which is the main cause of resistance to lamivudine, so cross-resistance is expected.
1) The oxidative phase generates NADPH The oxidative branch of the pathway generates NADPH and pentose-5-phosphate, through the following reactions: a) Glucose-6-pho
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