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Azoles
Systemic azole antifungals currently available in the US contain fluconazole (Diflucan, and others), itraconazole (Sporanox), voriconazole (Vfend) and ketoconazole (Nizoral, and others). All act by blocking the activity of 14-alpha-demethylase, leading to inhibition of ergosterol synthesis. They vary in their spectrum of activity, bioavailability, adverse effects and potential for drug interactions.
describe the mechanism of allosteric change.
What proportion of children with Down syndrome do you expect when women with Down syndrome have children with men who have 46 chromosomes justify your answer?
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