Explain about the chromium metabolism, Biology

Assignment Help:

Explain about the Chromium Metabolism?

Chromium appears to be absorbed throughout the small intestine, with absorption being higher in jejunum. The mechanism of absorption has not been well defined but appears to involve processes other than simple diffusion. At normal dietary intakes (10-40 mcg/day), the absorption ranges from 0.4 to 3.0% with absorption being higher at lower intakes. As you have studied for other minerals, even in the case of chromium, an inverse relation between intake and absorption appears to be a basal control mechanism to maintain the body levels of chromium. As compared to healthy individuals, insulin-dependent diabetic patients absorb 2-4 times more chromium. It appears that these patients have an impaired ability to convert inorganic form to usable form and therefore require higher chromium. Like other trace minerals, absorption of chromium is also influenced by some factors. Enhancers and inhibitors are listed in the Table.

Table: Factors influencing absorption

1300_Explain about the Chromium Metabolism.png

After absorption, chromium binds to plasma proteins for transportation. Both transferrin and albumin are capable of binding absorbed Cr. It has been suggested that transferrin is the main binder of newly absorbed chromium and albumin assumes the role of chromium acceptor and transporter if transferrin binding sites are unavailable. You have studied that transferrin has two metal binding sites, one is primarily for iron and the second is involved in chromium transport. During conditions of iron excess or iron overload such as iron storage diseases, all the metal transport sites on transferrin are occupied by iron. This may explain the high incidence of diabetes in haemochromatosis patients, which may be induced by chromium deficiency. Although transferrin and albumin play the major roles in transportation, other plasma proteins such as α and β globulins and lipoproteins are also involved. As you will go through the next section on 'Functions', you will realize that only organically complexed chromium i.e. GTF is active. It appears that absorbed inorganic chromium is transported to the liver, which is postulated to be the possible site for synthesis of metabolically active molecule. This molecule is held in a body pool and released as needed. Most ingested chromium is excreted in faeces. Inorganic chromium is excreted primarily by the kidney, with small amounts being excreted through hair, sweat and bile. Organically bound chromium is excreted through bile. The biologically active form of chromium performs several functions; the important ones are being subsequently discussed.


Related Discussions:- Explain about the chromium metabolism

Zoonoses disease-yabapox, Yabapox Yabapox is a disease affecting mangabeys...

Yabapox Yabapox is a disease affecting mangabeys, rhesus, cynos, vervets, stumptails, and patas monkeys. It is caused by the Yaba-like disease virus (YLDV) and Yaba monkey tumor v

What are the hormones that release of the female gamete, What are the hormo...

What are the hormones that promote the release of the female gamete from the follicle and at which day of the menstrual cycle does this phenomenon happen? What is this event called

What are the applications of nicotinic acid, What are the Applications of N...

What are the Applications of Nicotinic acid Nicotinic acid is mainly used in the vitamin fortification of flour, macaroni and noodle products. Independent of its vitamin effic

Query, How can I get assignment order

How can I get assignment order

What is the main moral problem about the cloning, What is the main moral pr...

What is the main moral problem about the cloning of human individuals? Besides biological perils, a very serious moral problem includes the nucleus transplantation technology c

Chemotaxis - modes of cell movement, Chemotaxis - Modes of Cell Movement ...

Chemotaxis - Modes of Cell Movement Chemotaxis considers to me directed movement of cells in response to a concentration gradient of a chemical factor in solution. An instance

Phosphorus - mineral elements, PHOSPHORUS It is present in vegetables, ...

PHOSPHORUS It is present in vegetables, grains (oat metal, wheat meal), milk, eggs, cheese, meat, fish, etc. It helps in - (a) Like calcium it is a constituent of bones.

Define role of vitamin a in controlling gene expression, Define role of Vit...

Define role of Vitamin A in controlling gene expression? Vitamin A as retinoic acid has widespread effects on the synthesis of a variety of important proteins. These diverse ef

Determine about the term - neuropsychology, Determine about the term - neur...

Determine about the term - neuropsychology The clinical practice of neuropsychology involves an integration of knowledge bases from the disciplines of psychology, psychometrics

Intermediate filaments - role of cytoskeleton structures, Intermediate fila...

Intermediate filaments - Role of Cytoskeleton Structures These filaments are intermediate in size among microtubules and microfilaments and are 10 nm in diameter. Five classes

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd