Explain about the chromium metabolism, Biology

Assignment Help:

Explain about the Chromium Metabolism?

Chromium appears to be absorbed throughout the small intestine, with absorption being higher in jejunum. The mechanism of absorption has not been well defined but appears to involve processes other than simple diffusion. At normal dietary intakes (10-40 mcg/day), the absorption ranges from 0.4 to 3.0% with absorption being higher at lower intakes. As you have studied for other minerals, even in the case of chromium, an inverse relation between intake and absorption appears to be a basal control mechanism to maintain the body levels of chromium. As compared to healthy individuals, insulin-dependent diabetic patients absorb 2-4 times more chromium. It appears that these patients have an impaired ability to convert inorganic form to usable form and therefore require higher chromium. Like other trace minerals, absorption of chromium is also influenced by some factors. Enhancers and inhibitors are listed in the Table.

Table: Factors influencing absorption

1300_Explain about the Chromium Metabolism.png

After absorption, chromium binds to plasma proteins for transportation. Both transferrin and albumin are capable of binding absorbed Cr. It has been suggested that transferrin is the main binder of newly absorbed chromium and albumin assumes the role of chromium acceptor and transporter if transferrin binding sites are unavailable. You have studied that transferrin has two metal binding sites, one is primarily for iron and the second is involved in chromium transport. During conditions of iron excess or iron overload such as iron storage diseases, all the metal transport sites on transferrin are occupied by iron. This may explain the high incidence of diabetes in haemochromatosis patients, which may be induced by chromium deficiency. Although transferrin and albumin play the major roles in transportation, other plasma proteins such as α and β globulins and lipoproteins are also involved. As you will go through the next section on 'Functions', you will realize that only organically complexed chromium i.e. GTF is active. It appears that absorbed inorganic chromium is transported to the liver, which is postulated to be the possible site for synthesis of metabolically active molecule. This molecule is held in a body pool and released as needed. Most ingested chromium is excreted in faeces. Inorganic chromium is excreted primarily by the kidney, with small amounts being excreted through hair, sweat and bile. Organically bound chromium is excreted through bile. The biologically active form of chromium performs several functions; the important ones are being subsequently discussed.


Related Discussions:- Explain about the chromium metabolism

What are the stages into which photosynthesis is divided, What are the stag...

What are the stages into which photosynthesis is divided? Photosynthesis is separated into the photochemical stage, or light reactions, and the chemical stage. Photosynthesi

The excretion by the human kidney, The excretion by the human kidneys 1...

The excretion by the human kidneys 1. Descending limb of Loop of Henle is impermeable to water 2. Distal convoluted tubule is incapable of reabsorbing HCO3 3. Nearly 99 p

What is the cell theory, Cell theory is a theory that asserts that the cell...

Cell theory is a theory that asserts that the cell is the ingredient unit of the living beings. Before the discovery of the cell, it was not examined that the living beings were

Animal biodiversity, Discuss why Obelia is considered to be of special inte...

Discuss why Obelia is considered to be of special interest in Zoology as an animal showing an intermediate grade of organization.

Determine the amount of vasopressin, Consider the case of a rare mutant in ...

Consider the case of a rare mutant in which the concentration of solutes in the kidney medulla interstitial spaces is equal to the concentration of solutes in the liquid in the lum

What is the relevance of knowing about gi of foods, What is the relevance o...

What is the relevance of knowing about GI of foods? Let us see how this index is helpful in prescribing therapeutic diets. You would realize that the dietary GI provides an ind

Coronal disassembly devices-grasping instruments, Grasping instruments ...

Grasping instruments -Plier or clamp forceps -put piece of rubber in the plier                                 -applied on the buccal and lingual surface -make pressure to

Explain the effect of deficiency of pyridoxine, Explain the effect of Defic...

Explain the effect of Deficiency of pyridoxine? A deficiency of vitamin B6 alone is uncommon because it usually occurs in association with a deficit in other B-complex vitamin

Define end and the beginning of the first interphase period, Q. What are th...

Q. What are the events that mark the end and the beginning of the first interphase period? What happens inside the cell in this period? The initial interphase period is the G1.

How do chordates reproduce, Q. How do chordates reproduce? Reproduction...

Q. How do chordates reproduce? Reproduction in beings of the phylum Chordata is sexual, with the exception of urochordates that can be also reproduce asexually. In some classes

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd