Explain about the chromium metabolism, Biology

Assignment Help:

Explain about the Chromium Metabolism?

Chromium appears to be absorbed throughout the small intestine, with absorption being higher in jejunum. The mechanism of absorption has not been well defined but appears to involve processes other than simple diffusion. At normal dietary intakes (10-40 mcg/day), the absorption ranges from 0.4 to 3.0% with absorption being higher at lower intakes. As you have studied for other minerals, even in the case of chromium, an inverse relation between intake and absorption appears to be a basal control mechanism to maintain the body levels of chromium. As compared to healthy individuals, insulin-dependent diabetic patients absorb 2-4 times more chromium. It appears that these patients have an impaired ability to convert inorganic form to usable form and therefore require higher chromium. Like other trace minerals, absorption of chromium is also influenced by some factors. Enhancers and inhibitors are listed in the Table.

Table: Factors influencing absorption

1300_Explain about the Chromium Metabolism.png

After absorption, chromium binds to plasma proteins for transportation. Both transferrin and albumin are capable of binding absorbed Cr. It has been suggested that transferrin is the main binder of newly absorbed chromium and albumin assumes the role of chromium acceptor and transporter if transferrin binding sites are unavailable. You have studied that transferrin has two metal binding sites, one is primarily for iron and the second is involved in chromium transport. During conditions of iron excess or iron overload such as iron storage diseases, all the metal transport sites on transferrin are occupied by iron. This may explain the high incidence of diabetes in haemochromatosis patients, which may be induced by chromium deficiency. Although transferrin and albumin play the major roles in transportation, other plasma proteins such as α and β globulins and lipoproteins are also involved. As you will go through the next section on 'Functions', you will realize that only organically complexed chromium i.e. GTF is active. It appears that absorbed inorganic chromium is transported to the liver, which is postulated to be the possible site for synthesis of metabolically active molecule. This molecule is held in a body pool and released as needed. Most ingested chromium is excreted in faeces. Inorganic chromium is excreted primarily by the kidney, with small amounts being excreted through hair, sweat and bile. Organically bound chromium is excreted through bile. The biologically active form of chromium performs several functions; the important ones are being subsequently discussed.


Related Discussions:- Explain about the chromium metabolism

State the definition of respiration, State the Definition of respiration ...

State the Definition of respiration Respiration is an act of breathing. (i.e. rise and fall of the chest).  Respiration hastwo parts i.e. inhalation and exhalation. When we bre

Why roots of many swamp plants have a special morphology, Why roots of many...

Why roots of many swamp plants have a special morphology? The Swamp and The marsh plants in general present supporting roots that ramify from portions of the stem above the gro

Explain the formation of the enzyme-substrate complex, What are the main th...

What are the main theoretical models that try to explain the formation of the enzyme-substrate complex? There are two major models that explain the formation of the enzyme-subs

What is the importance of vitamin A, What is the importance of vitamin A ...

What is the importance of vitamin A The importance of vitamin A is undisputable. You may already be aware about the functions/role of vitamin A in our body.  Vitamin A is absol

Use of neurotensin in consciousness, Q. Use of Neurotensin in consciousness...

Q. Use of Neurotensin in consciousness? Although little is known about the role of this peptide during the sleep-wake cycle, it has recently been shown that neurotensin injecti

What is meiosis, What is Meiosis ? Meiosis starts with a diploid cell a...

What is Meiosis ? Meiosis starts with a diploid cell and forms four haploid, or 1n, (or "n") germ cells. These n germ cells fuse during fertilization with another germ cell to

Hypomagnesaemic tetany , Hypomagnesaemic tetany (grass tetany, grass stagge...

Hypomagnesaemic tetany (grass tetany, grass staggers, lactation tetany) Hypomagnesaemic tetany is a multifactorial complex metabolic disorder, which is  characterized by reduct

What is biological control, What is biological control? Biological cont...

What is biological control? Biological control is a natural process to control the size of animal, microorganism or plant populations. Biological control is based on the knowle

Explain guar gum, Guar Gum Guar Gum is derived from seed of legume Cyam...

Guar Gum Guar Gum is derived from seed of legume Cyamopsis tetragonalobus resembling soyabean plant. Guar gum is composed of Galactomannan Galactose: mannose in the ratio 1:2.

Energy demand for vigorous or vigorously active lifestyles, Determine Energ...

Determine Energy demand for Vigorous or vigorously active lifestyles? These people engage regularly in strenuous work or in strenuous leisure activities for several hours. Exam

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd