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Which of the following mediates the interactions among the splicing machinery and the mRNA transcript?
A. Alpha helical structures within the RNA binding domain of the splicing proteins interact with the nucleotide sequence of the mRNA transcript.
B. The positively charged splicing proteins interact with the negatively charged mRNA transcript by non-specific charge interactions.
C. Non-Coding RNAs that associate with the splicing proteins form complementary base pairing with the nucleotides of the mRNA transcript.
D. The splicing proteins are recruited to the splice sites within the mRNA by recognition of methylated RNA nucleotides.
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