Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

What are plant root hairs, What are plant root hairs? Where can they found ...

What are plant root hairs? Where can they found and what is their function? The Root hairs that are external elongated projections of the root epidermis and their role is to in

What is the difference between nematocyst and spicules, What is the differe...

What is the difference between nematocyst and spicules? Nematocysts are on Cnidarians Spicules are in Poriferae

ALGAE., HOW ARE THE ORIGIN AND EVOLUTION OF ALGAE..

HOW ARE THE ORIGIN AND EVOLUTION OF ALGAE..

Explain creaming volume formulae - performance evaluation, Performance Eval...

Performance Evaluation Cake batter aeration can be affected by the plasticity, consistency, emulsification, bake stock formulation and other fats and oil properties.  Creamin

Deer, How does a deer feed

How does a deer feed

Y-linked traits in humans, Y-Linked traits in humans Any gene that occu...

Y-Linked traits in humans Any gene that occurs exclusively on the Y chromosome is said to be holandric and it is not expressed in females. Such a Y-linked gene normally occurs

What is embryogenesis explain in detail, What is Embryogenesis explain in d...

What is Embryogenesis explain in detail? Embryogenesis in humans consists of the first eight weeks of development of the zygote. Embryogenesis in animals is generally divided i

Nutrition affecting the growth of microorganism, Q. Can Nutrition affecting...

Q. Can Nutrition affecting the growth of microorganism? Ans. Food is food to humans and microbes - be it carbohydrates, proteins or fats. The nutritional requirements of b

How delayed complementary feeding cause pem, How Delayed Complementary Feed...

How Delayed Complementary Feeding Cause PEM? The mothers from poorer socioeconomic groups where PEM is more prevalent, delayed introduction of complementary foods (foods in add

Define the rehabilitation phase of spinal trauma disease, Define the Rehabi...

Define the Rehabilitation Phase of spinal trauma disease? Once the patient s condition stabilizes, individualized diets need to be recommended, based on the energy and nutrient

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd