Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

Where in the process does this chemical element take part, Until the Krebs ...

Until the Krebs cycle, aerobic respiration can be explained without mentioning oxygen, the chemical element after which the reaction gets its name. Where in the process does this c

Illustrate briefly about titanium, Illustrate briefly about titanium I...

Illustrate briefly about titanium It is generally accepted that pure titanium has little cytotoxicity and it is suggested that the plaque induced inflammation may be due to cr

Difference between an ecological niche and a habitat, What is the differenc...

What is the difference between an ecological niche and a habitat? An ecological niche is a set of peculiar activities, resources and methods that a species explores to survive

Light and heavy soils-physical properties of soil, Light and Heavy Soils ...

Light and Heavy Soils The presence of silt and especially clay in a soil imparts to it a fine texture, and a slow water and air movement. Such a soil is highly plastic becoming

Need help!!!, im stuck on this question where we have to make a table of av...

im stuck on this question where we have to make a table of averages using quadrats and transect lines can you help me?

Show the physical criteria of quality for honey, Q. Show the Physical crite...

Q. Show the Physical criteria of quality for Honey? Colour, crystallization, pH, acidity, water content are some of the criteria used for analysis of honey. These criteria are

Three phases into which the cell respiration is divided, What are the three...

What are the three phases into which the cell respiration is divided? The three phases of aerobic cell respiration are glycolysis, Krebs cycle and respiratory chain (also calle

Need for insulin in management of type 1 diabetes mellitus, Q. Need for ins...

Q. Need for insulin in management of Type 1 Diabetes Mellitus? Type 1 Diabetes Mellitus occurs when the body's immune system destroys beta cells. Beta cells produce insulin, a

Define paediatric problems and nutritional management, Define Paediatric Pr...

Define Paediatric Problems and Nutritional Management? The process of accepting and digesting food in adequate amounts to meet nutrition needs is termed as feeding. Certain gro

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd