Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

Explain about the oral cavity and alimental-y tract, Explain about the Oral...

Explain about the Oral cavity and alimental-y tract? Various functional changes and decline in secretary function occur in the digestive tract with aging. These include: Or

What is meant by concentration gradient, What is meant by concentration gra...

What is meant by concentration gradient? Is it correct to refer to "concentration gradient of water"? Concentration gradient is the difference of concentration of a substance

Spontaneous deamination of cytosine, Q. Spontaneous deamination of cytosine...

Q. Spontaneous deamination of cytosine: 1. Deamination of cytosine is common and results in conversion of cytosine to uracil 2. can be repaired by excision repair process (i)

Explain what is class osteichthyes , Explain what is Class Osteichthyes ? ...

Explain what is Class Osteichthyes ? Class Osteichthyes takes its name from the Greek root "osteo," referring to bone, and "ichthys," referring to fish. The bony fish have a sk

Life forms - qualitative characters, Life Forms - Qualitative Characters ...

Life Forms - Qualitative Characters The form and structure of terrestrial communities are determined by the nature of vegetation. Vegetation may be classified according to gro

Why food which can be taken in plenty, Food Which can be Taken in Plenty an...

Food Which can be Taken in Plenty and Food to be Avoided Lastly, in the context of changing the diet, we should know the foods to be avoided and the food to be taken in plenty

How can you describe pleural effusion, Q. How can you describe Pleural Effu...

Q. How can you describe Pleural Effusion? Fluid has a density indistinguishable from soft tissue on a radiograph. Pleural fluid tends to accumulate in the deepest part of the

Deficiency diseases-metabolic disorders, Metabolic Disorders The disea...

Metabolic Disorders The disease conditions, which are attributable to an imbalance between rates of input of dietary nutrients and the output of production, are defined as pro

Disorders of motor neurons and the spinal cord, Disorders of motor neurons ...

Disorders of motor neurons and the spinal cord A number of movement disorders are produced by damage either to the spinal cord or to cortical projections to the spinal cord. Th

Shapes of viruses, Shapes of viruses Viruses occur in a wide variety o...

Shapes of viruses Viruses occur in a wide variety of shapes. Some are spherical or polyhedral . Some are helical appearing cylindrical or rod-like and other are complex. Virus

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd