Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Infant botulism, In infant botulism, viable botulinal spores are ingested a...

In infant botulism, viable botulinal spores are ingested and upon germination in the intestinal tract, toxin is synthesized. It is confined to infants under a year of age. High num

Solid waste management, All Solid Semi-Solid Wastes Arising From Human And ...

All Solid Semi-Solid Wastes Arising From Human And Animals Activities, Except Human Excreta And Sullage (Liquid Wastes From Bathrooms, Kitchens Etc.) are discarded as useless or un

Determine the categories of sleep disorders, Determine the categories of sl...

Determine the categories of sleep disorders Sleep disorders are generally divided into two major groups: 1) Narcolepsy, which is characterised by excessive sleep or brief in

What is calvin cycle, What is Calvin Cycle? The dark reactions of photo...

What is Calvin Cycle? The dark reactions of photosynthesis are also known as the Calvin cycle. This process synthesizes glucose molecules using carbon dioxide from the atmosphe

Counselling for day to day management, Q. Counselling for day to day Manage...

Q. Counselling for day to day Management? As we know that diabetes is a chronic disease, a major part of its control requires counselling the patient and his family for day to

Diagrammatic representation of implant placement, Diagrammatic representati...

Diagrammatic representation of Implant placement Implant placementIt is located directly apical to the tooth it is replacing and not in an embrasure space. The angulati

Osmosis, If you have water, 10% sucrose, and 40% sucrose solution. Which so...

If you have water, 10% sucrose, and 40% sucrose solution. Which solutions were isotonic to each other?

Diabetic foot are impaired blood supply to foot, Diabetic foot are impaired...

Diabetic foot are impaired blood supply to foot Diabetic foot are impaired blood supply to foot i.e. vasculopathy. This leads to ischaemia which in turn leads to delayed or non

What is endocytosis , Endocytosis is the uptake of extracellular macr...

Endocytosis is the uptake of extracellular macromolecules   across the plasma membrane into the cell. The objects to be ingested is progressively  enclosed by a  small  portion  of

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd