Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Who is known as father of english botany, Who is known as Father of English...

Who is known as Father of English Botany? William Turner (1515-1568), whose 'A New Herbal' printed in English appeared in 1551 (first part), 1562 (second part) and 1568 (third

Write the meaning of dsme, Q. Write the meaning of DSME? Generally, it ...

Q. Write the meaning of DSME? Generally, it is observed that soon after being diagnosed with diabetes, the patient gets worried or get depressed. This is a stage where the pati

Control of radio-pollution , (i)        Area uses or perm...

(i)        Area uses or permit exposure to radiation should be Marked' Restricted Area 'or Radiation zone etc. (ii)        Avoid x-rays of chest and lower back in routine physic

Gastrointestinal tract function , Gastrointestinal Tract Function: As...

Gastrointestinal Tract Function: As a result of burn  injury acute gastric dilation occurs, creating abdominal distention and  regurgitations. Malabsorption occurs secondary

Lipid digestion, Lipid Digestion Digestion of fats is also similar in...

Lipid Digestion Digestion of fats is also similar in both invertebrates and vertebrates. Lipases are the - enzymes that hydrolyse fats. A single lipase can catalyse many step

Proteins of the endoplasmic reticulum, The RER have various proteins which ...

The RER have various proteins which have the role of assisting nascent proteins to fold rightly into their native conformation. Some of these are called as chaperones. RER-resident

Where are blood cells made in the body, Where are blood cells made in the b...

Where are blood cells made in the body? Blood cells are made in the red bone marrow, e.g. in the ribs, sternum or vertebrae.

Explain biochemical investigation, Explain Biochemical investigation Bi...

Explain Biochemical investigation Biochemical  investigations:  These help  to  reveal nutrients and metabolites in blood and /or urine, and/or faeces that indicate an infectio

Determine the osseus defects around implants, Osseus defects around implant...

Osseus defects around implants. They are classified into four main groups. Group I defects: These demonstrate moderate horizontal bone loss with a minimal intrabony component

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd