Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Illustrate about human eyes, Eyes We have a pair of eyes. They are held...

Eyes We have a pair of eyes. They are held in socket of the skull by four rectus muscles and two oblique muscles. These muscles control the movements of the eyes. The wall of t

Egg drop syndrome-76 (eds-76), E g g drop syndrome-76 (EDS-76) An out...

E g g drop syndrome-76 (EDS-76) An outbreak of sudden drop in egg production or a failure to achieve a normal peak in production despite optimum managemental and nutrition st

Structural variations in vertebrate kidney, Normal 0 false fa...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Evaluation of osseointegration, Q. Evaluation of osseointegration? All ...

Q. Evaluation of osseointegration? All the parameters of proper implant selection, atraumatic sequential osteotomy preparation and the attainment of primary stability are focus

#zoology, what is amniocentosis

what is amniocentosis

Define the symptoms of yersinia enterolytica infection, Normal 0 ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4 Define the Symptoms

Avian (fowl cholera), Avian (fowl cholera) Fowl cholera is a contagious...

Avian (fowl cholera) Fowl cholera is a contagious septicaemic disease of almost all classes of fowl. The causal agent is Pasteurella multocida.Serotypes A:1 and A:3 are usually

Contraceptive methods, Contraceptive methods The safe and easy methods ...

Contraceptive methods The safe and easy methods to prevent pregnancy are called contraceptive methods. i) Contraceptive methods followed by females are : 1) Use of harmon

Define the water bath with shaker, Define the Water Bath with Shaker? A...

Define the Water Bath with Shaker? An electric water bath with a shaker that can hold test tubes as well as conical flasks. When on a non-shake mode, it acts as a simple water

Determine the glycogen receptors in the plasma membranes, Which of the foll...

Which of the following serves as an effector, or as part of an effector, that functions in a negative feedback system? A. Glycogen Receptors in the plasma membranes of liver ce

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd