Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

What is ceramics, What is Ceramics A kind of material that is "bone lik...

What is Ceramics A kind of material that is "bone like" based on the specific ratios of calcium and phosphorous in particular crystalline structures. Ceramics are inorganic, no

Calculate the volume of a 25% urethane solution, Assume that the blood volu...

Assume that the blood volume of a rabbit is 0.5 liters. If the effective dose of the anesthetic urethane is 10 micrograms/mL, calculate the volume of a 25% urethane solution that m

What is the probability the child will have pku, PKU is a recessive disorde...

PKU is a recessive disorder. Suppose two people who were heterozygous for PKU married and had a child. What is the probability that the child will have PKU?

Causes of reduced serum hdl levels, Q. Causes of reduced Serum HDL levels? ...

Q. Causes of reduced Serum HDL levels? Possible causes of reduced Serum HDL levels: - Cigarette smoking - Hypertriglyceridemia - Obesity - Genetic factors - Lack

List the two primary targets to assess good sugar control, List the two pri...

List the two primary targets to assess the good sugar control 1) There are two primary targets to assess the effectiveness of the management plan on glycemic (sugar) controls.

Nicotinic acid or niacin, Niacin affects all lipid parameters favorably. It...

Niacin affects all lipid parameters favorably. It is one of the only agents that reduces Lp (a) significantly (up to 30 per cent). Unfortunately, compliance is poor because of freq

What are biogeochemical cycles, Q. What are biogeochemical cycles? The ...

Q. What are biogeochemical cycles? The Biogeochemical cycles are representations of the circulation and recycling of matter in nature. The major biogeochemical cycles studie

What are social dangers, Members belonging to the scientific community fear...

Members belonging to the scientific community fear the misuse of this therapy leading to dangerous consequences.  People may try to insert the desired gene, for example, the gene f

Respiration, how does respiration in animals occur? what is respiration? wh...

how does respiration in animals occur? what is respiration? what are the common types of respiration?

What is the energy source used in active transport, What is the energy sour...

What is the energy source used in active transport through biological membranes? The energy essential for active transport (against the concentration gradient of the transporte

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd