Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Iaa stimulates cell enlargement, IAA Stimulates Cell Enlargement Cell...

IAA Stimulates Cell Enlargement Cell wall contains layer of cellulose fibrils and are normally quite rigid. Thus for a cell to grow, there must be a mechanism for relaxing th

Monoclonal antibody, Monoclonal Antibody is an antibody with quite specifi...

Monoclonal Antibody is an antibody with quite specific and often unique binding specificity which is secreted by the biologically cloned line of plasmacytoma cells in the absence

State the terms - blastocoel and blastopore, State the terms - Blastocoel a...

State the terms - Blastocoel and Blastopore? During the development of embryo, single cells divide and form a hollow ball of cells one cell layer thick. Cavity inside this holl

Neutral fat & oils, Neutral fat & oils These are triglyceryde compou...

Neutral fat & oils These are triglyceryde compounds. 1 molecule of neutral fat consists of 1 molecule of glycerole and 3 molecule of fatty acids. 3 ester bo

What is osmotic pressure, Q What is osmotic pressure? Osmotic pressure ...

Q What is osmotic pressure? Osmotic pressure is the pressure produced in an aqueous solution by a region of lower solute concentration upon a region of higher solute concentrat

Determine about the the halstead category test, Determine about the The Hal...

Determine about the The Halstead Category Test  This test is a concept identification procedure in which the subject must discover the method or principle that governs various

Determine the food source for phosphorus, Determine the Food Source for Pho...

Determine the Food Source for Phosphorus? Phosphorus is widely distributed in food. Food phosphorus is a mixture of both organic and inorganic forms although the relative amoun

Silviculture, Silviculture: It concerned with the cultivation of timber yi...

Silviculture: It concerned with the cultivation of timber yielding plants. Silviculture is the way of controlling the growth, establishment, composition, health or quality of fore

Industrial processes that use bacteria, Q. What are few industrial processe...

Q. What are few industrial processes that use bacteria? Bacteria are used by industry in different ways. There are vaccines made of antigens present in bacteria or of attenuate

Posterior leaflet-technique of operation, Posterior Leaflet: In the poste...

Posterior Leaflet: In the posterior leaflet a quadrangular excision of the sector involved in the prolapse is done. This may be up to 15-20 per cent of the leaflet. The remaining

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd