Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Define osmotic pressure - properties of solutions, Explain Osmotic Pressure...

Explain Osmotic Pressure Osmosis, as you may already know, refers to the flow of solvent into a solution, or from a more dilute solution to a more concentrated solution, when t

What is inertization, Q. What is Inertization? The process of "inertiza...

Q. What is Inertization? The process of "inertization" involves mixing waste with cement and other substances before disposal in order to minimize the risk of toxic substance c

Codominance, CODOMINANCE The alleles which do not show dominance-recess...

CODOMINANCE The alleles which do not show dominance-recessive relationship and are able to express themselves independently when present together are called codominant alleles.

Stems transport liquids, Stems transport liquids (a)  Cut about 2 cm fr...

Stems transport liquids (a)  Cut about 2 cm from the end of stems of celery and place them in cold water for about an hour to freshen. Next place the stems in dishes having red

Explain aerobic cellular respiration during muscle exercise, What happens w...

What happens when the oxygen supply is insufficient to maintain aerobic cellular respiration during muscle exercise? If oxygen from hemoglobin or myoglobin is not enough for th

Explain the effect on minerals of the human milk, Explain the effect on Min...

Explain the effect on Minerals of the Human milk? There appears to be no relationship between dietary intake and concentrations in milk for copper, iron or zinc. Iron supplemen

Dietary recommendations during diarrhoea, Q. Dietary Recommendations during...

Q. Dietary Recommendations during Diarrhoea? The diet should take into account the normal RDI and various adjustments made to the quantity and quality of the foods to be given.

Indication in circulatory assist devices, Indication :  IABP is commonly u...

Indication :  IABP is commonly used to supporting failing left ventricle after open-I1ca1-t surgery or in cardiogenic shock after myocardial infarction. It is at times used in uns

What do you mean by dicoumarol, Q. What is dicoumarol? How does this substa...

Q. What is dicoumarol? How does this substance act in the clotting process and what are some examples of its toxicity? Coumarinic anticoagulants cannot be administered during p

Hypothermia-open heart surgery, Hypothermia :  Hypothermia reduces the met...

Hypothermia :  Hypothermia reduces the metabolic requirements of the body thereby reducing oxygen consumption. It also preserves high-energy phosphate stores of the body. At norma

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd