Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Explain antiarrhythmic drugs, Explain Antiarrhythmic Drugs? Amiodarone ...

Explain Antiarrhythmic Drugs? Amiodarone may be considered in VT/VF that is refractory to shock. It might be given if the third shock is not successful. The dose is 300 mg IV i

Body temperature and room temperature , You ran both a body temperature and...

You ran both a body temperature and room temperature test for each enzyme you tested. Did the two temperatures seem to have an effect on the enzyme Exercise? Why or why not?

How does the structure of a chloroplast enable, How does the structure of a...

How does the structure of a chloroplast enable it to build up a concentration gradient of protons?  Chloroplasts have an inner membrane system having of thylakoids. The pumpin

Bio-security in relation to diseases, B i o-security in relation to disea...

B i o-security in relation to diseases Bio-security is a strategic and integrated approach encompassing policy and regulatory frameworks to analyze and manage risks in the se

Explain starch gelatinization, Starch gelatinization Undamaged starch ...

Starch gelatinization Undamaged starch granules are insoluble in cold water but can imbibe water  reversibly i.e. they can swell slightly and then return to their original siz

Expressed sequence tag (est), Expressed sequence tag (EST) is the short pa...

Expressed sequence tag (EST) is the short part of DNA sequence of corresponding to the fragment of the complementary DNA (made from the cell's messenger RNA). ESTs have been taken

Soil-environmental components, Soil-Environmental Components The word s...

Soil-Environmental Components The word soil is derived from Latin word 'solum' meaning earthy material in which plants grow. The soil is the consolidated outer layer of the ear

Explain the direct surface agar plating method, Explain the Direct Surface ...

Explain the Direct Surface Agar Plating Method? In the direct surface agar plating method, molten agar is placed on to the surface to be assessed. Upon hardening, it is incubat

Can two organisms share the similar kingdom, If two organisms share the sim...

If two organisms share the similar kingdom, must they also share the similar domain? Explain. Two organisms that share the similar kingdom must also share the similar domain b

How antigen react against future infection by same agent, Q. How can an org...

Q. How can an organism that once underwent contact with an antigen be immunized against future infections by the same agent? This phenomenon is called as immune memory when an

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd