Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Define the characteristics that are seen in rickets, Define the characteris...

Define the characteristics that are seen in Rickets? The following characteristics are seen in fully developed cases of rickets: 1) In case of young infants, delayed closure

Insulin, INSULIN Linear polymer of b-D-Glucose. Insulin is small-...

INSULIN Linear polymer of b-D-Glucose. Insulin is small-sized (25 - 35 residues) fructosan homopolysaccharide which is a reserve carbohydrate present in roots, tubers and

Zoonoses disease- histoplamosis, Histoplamosis Caveran disease, darling’s ...

Histoplamosis Caveran disease, darling’s disease, reticuloendothelial cytomycosis or tingo maria fever are the other synonyms for histoplamosis caused by Histoplasma capsulatum. T

Define reagents required for osazone test, Define Reagents Required for Osa...

Define Reagents Required for Osazone Test? - Solutions of glucose, galactose,fructose, lactose, maltose, sucrose. - Phenyl hydrazine mixture (2 parts of Phenylhydrazine hydr

Evolution of the cell, EVOLUTION OF THE CELL All the living organisms a...

EVOLUTION OF THE CELL All the living organisms are made up of cells. A living cell may be defined as a compartment enclosed by a membrane that consists of several chemical cons

Sample titration for estimation of vitamin c in lemon juice, Define Sample ...

Define Sample Titration for Estimation of Vitamin c in Lemon Juice? Cut the lemon into two halves with a stainless steel knife. Remove the seeds. Squeeze the juice from half a

Can you explain bayesian theorem, Q. Can you explain Bayesian Theorem? ...

Q. Can you explain Bayesian Theorem? Bayesian Theorem: The predictive value of a test is related to the incidence of disease in the population. A history of typical angin

Respiration, define respiration in diffrent types of animals

define respiration in diffrent types of animals

Person''s red blood cell content of 2, How would carbon monoxide poisoning ...

How would carbon monoxide poisoning affect a person's coloring, particularly of the mucous membranes? How would it affect the hemoglobin concentration, hematocrit, and percent oxyh

<-- that guy, thy does he look too excited in the illistration?

thy does he look too excited in the illistration?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd