Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Define etiological risk factors in cancer - genetic factors, Define etiolog...

Define etiological risk factors in cancer - Genetic Factors? Some cancers are programmed by genes to develop. Gene mutations result from one or more regulatory genes in the cel

What is hmp pathway, What is HMP pathway? Give any two points of its signif...

What is HMP pathway? Give any two points of its significance The HMP  is an alternate oxidative pathway for the metabolism of glucose. The significance of the pathway  is that

Gametogenesis - human development, Gametogenesis - Human Development G...

Gametogenesis - Human Development Gametogenesis as you are responsive is the process of formation and development of specialized reproductive cells, ova in females and sperms

Taxonomy, what is the taxonomic classification for the protist Archaeplasti...

what is the taxonomic classification for the protist Archaeplastida?

Endoplasm and ectoplasm, Normal 0 false false false EN-...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Explain the digestive system, Explain the Digestive System ? The diges...

Explain the Digestive System ? The digestive system takes in food and processes it. Digestion is the mechanical and chemical breaking down of food into a form that can be used

Explain adverse effects of ganciclovir, Explain Adverse Effects of ganciclo...

Explain Adverse Effects of ganciclovir Ganciclovir is teratogenic, carcinogenic and mutagenic and causes aspermatogenesis in animals. Granulocytopenia and thrombocytopenia, whi

Describe retroviruses and how do they reproduce, Q What are the retroviruse...

Q What are the retroviruses? How do they reproduce and what is the role of the enzyme reverse transcriptase? Retroviruses are viruses whose genetic material is RNA, HIV and the

Pathophysiology of valvular heart diseases, Pathophysiology   Large hae...

Pathophysiology   Large haemorrhages and fibrinous lesions vegetate along the inflaked edges of valves. The lesions develop on adjacent valve leaflets so that the edges adh

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd