Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Which hormones secreted by adrenal medulla, Q. What are the hormones secret...

Q. What are the hormones secreted by the adrenal medulla? What are their respective functions? The medullary portion of the adrenals secretes hormones of the catecholamine grou

Define the elements that affects the fitness, Define the elements that affe...

Define the elements that affects the Fitness? Fitness varies from a person to person. It is influenced by age, sex, heredity, personal habits, exercise and eating practices. Th

Lymph, Why lymph is also called middle man of body

Why lymph is also called middle man of body

Response to wounding, Response to Wounding Wounding of tomato plants b...

Response to Wounding Wounding of tomato plants by mechanical injury or chewing by insects releases a factor that triggers accumulation of two proteinase inhibitors-throughout

How many asymmetric the amino acid serine have, How many asymmetric carbons...

How many asymmetric carbons does the amino acid serine have? Please explain with a strucutral diagram if possible.

Chlorophyll and haemoglobin, dialouge on cartoon between chlorophyll and ha...

dialouge on cartoon between chlorophyll and haemoglobin

What are the main events of the first mitotic period, What are the main eve...

What are the main events of the first mitotic period? The first mitotic period is prophase. During prophase the following events happen: migration of each centriole pair (centr

Defense mechanisms of the body against harmful agents, Q. What are the two ...

Q. What are the two groups of defense mechanisms of the body against harmful agents or foreign? What is the difference between them? The body has many defense mechanisms agains

Explain simple sugar, Simple sugars are monosaccharides consisting of a si...

Simple sugars are monosaccharides consisting of a single polyhydroxy aldehyde or ketone unit. Their general formula is (CH 2 0) n (n=3 to 7).

Where does calvin cycle take place in chloroplast, Where does Calvin cycle ...

Where does Calvin cycle take place in chloroplast? Explain the cycle. a) Where is electron transport system operative in mitochondria? b) Explain the system highlighting the

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd