Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Explain the cardiovascular effects, Explain the Cardiovascular Effects? ...

Explain the Cardiovascular Effects? You must have heard of the 'French Paradox'. The lower incidence of heart attacks in certain areas of France despite higher prevalence of fa

Munch pressure flow model, Munch Pressure Flow Model Munch, a German p...

Munch Pressure Flow Model Munch, a German plant physiologist, proposed in 1930, a simple physical model which can be tested in the laboratory for the mechanism of phloem trans

Explain healthy nutrition, Explain Healthy nutrition There is no doubt...

Explain Healthy nutrition There is no doubt that adoption of Healthy nutrition lifestyle and the practice of good nutrition habits would help eliminate many health problems ca

Carditis, It has been shown by prospective studies that Rheumatic heart dis...

It has been shown by prospective studies that Rheumatic heart disease (RHD) is linked to the occurrence of carditis during the first episode of ARF. If the first episode is accompa

Define eggs as a rich source of protein, Define Eggs as a rich source of pr...

Define Eggs as a rich source of protein? Roughly, the chicken egg consists of 11% shell, 31% yolk and 58% white. Liquid whole egg consists of 65% white and 35% yolk. The primar

Explain the lactose fermenters and non lactose fermenters, Explain the Lact...

Explain the Lactose Fermenters and Non lactose Fermenters 1) Lactose Fermenters - These produce acid on lactose fermentation, which results in red colouration on bacterial colo

Auxiliary food chains, Auxiliary Food Chains In addition to grazing an...

Auxiliary Food Chains In addition to grazing and detritus food chains there are other auxiliary food chains operated through parasites and scavengers. Some parasitic food chai

Illustrate the categories of alloplastic implant materials, Categories of a...

Categories of alloplastic implant materials The entire groups of possible alloplastic implant materials, regardless of their clinical applications fall into the following categ

Limb regeneration in anuran amphibians, Limb Regeneration in Anuran Amphibi...

Limb Regeneration in Anuran Amphibians We are already aware that the limb of adult frogs does not regenerate later than amputation. Though, some regeneration has been found to

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd