Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Why low ca++ in the body fluid cause in body, Low Ca ++ in the body fluid ...

Low Ca ++ in the body fluid may be the cause of: 1.  Tetany 2. Anaemia 3. Angina pectoris 4. Gout  Tetany cause low ca ++

Explain the glycemic index in chronic diseases, Explain the Glycemic index ...

Explain the Glycemic index in Chronic Diseases? In addition to serve as an aid in planning diets for diabetics, GI of diets has been linked to a number of chronic diseases. Sev

Mucopolysaccharides, MUCOPO L YSACCHARIDES They are heteropolysacc...

MUCOPO L YSACCHARIDES They are heteropolysaccharides of high molecular weight that are gelatinous is consistency, functioning in lubrication and as sticky substances in or

Abolition of arrhythmias by exercise, Q. Abolition of Arrhythmias by Exerci...

Q. Abolition of Arrhythmias by Exercise? The induction of arrhythmias by exercise is well recognized, but the abolition of ectopic activity is less commonly appreciated. The me

Explain changes in gastrointestinal tract of infants, Explain changes in ga...

Explain changes in gastrointestinal tract of infants? A full term baby has the ability to digest simple proteins, carbohydrates and emulsified fats. In first 3-4 months, the p

Chapter-2, multiple choise question

multiple choise question

What is diverticular disease, Q. What is Diverticular Disease? A common...

Q. What is Diverticular Disease? A common disorder of the large bowel, diverticulosis, is an early stage of the disease. It can be identified in 15% of the people over the age

What are the differences between mitosis and meiosis, Concerning their fina...

Concerning their final products (daughter cells and their ploidies) what are the differences between mitosis and meiosis? In mitosis one cell, for example, with 2n chromosomes,

Define phosphorous distribution in plasma, Define Phosphorous distribution ...

Define Phosphorous distribution in plasma? In plasma, phosphorus is distributed in different forms. Figure: Phosphorous distribution in plasma Inorg

Choline, CHOLINE Found in egg liver & kidney. Synthesized in body...

CHOLINE Found in egg liver & kidney. Synthesized in body with acetyle coA. It forms acetylcholine. Deficiency causes damage to kidney.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd