Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Define corneal xerosis - micronutrient deficiencies, Define Corneal Xerosis...

Define Corneal Xerosis - Micronutrient Deficiencies? This is a sign of severe vitamin 'A' deficiency, in which the cornea loses its normal smooth and glistening appearance and

Gene vs mrna , Obtain the sequence for the gene and the sequence for the RN...

Obtain the sequence for the gene and the sequence for the RNA transcript in FASTA format. If there is more than one transcript choose and appropriate one and explain your choice. U

Formation of egg membrane, FORMATION OF EGG MEMBRANE Ovum with egg memb...

FORMATION OF EGG MEMBRANE Ovum with egg membrane is called ova / egg.  On the basis of origin the egg membrane are of three types & 1 .      PRIMARY EGG MEMBRANE It is

Lab safety, Why should you not apply cosmetics while doing a lab experiment...

Why should you not apply cosmetics while doing a lab experiment in class?

Why is the amazon rainforest under risk of desertification, Q. Despite havi...

Q. Despite having a great biodiversity why is the Amazon Rainforest under risk of desertification? The natural soil of the Amazon Rainforest isn't very fertile but it is enrich

Explain the tubal ligation, Explain the Tubal Ligation   This process i...

Explain the Tubal Ligation   This process is the most commonly utilized method of female sterilization. Tubal ligations are generally done in an outpatient surgical center. Thr

Interactions between minerals, Interactions between minerals Copper de...

Interactions between minerals Copper deficiency has been identified as a serious problem for grazing ruminants. A deficiency may be due to low concentrations of Cu in forage a

Reagent for separation of amino acid by paper chromatography, Define Reagen...

Define Reagent for Separation of Amino Acid by Paper Chromatography? The following reagents will be required for carrying out the experiment: 1. Amino acid solution- Weig

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd