Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Division phase or mitosis, DIVISION PHASE OR MITOSIS (M- PHASE) Cell di...

DIVISION PHASE OR MITOSIS (M- PHASE) Cell division was first  observed by  Naegeli 1842 in plant cells ,but  thoroughly described by Eduard strasburger  1875. Fleming 1879 desc

Enumerate various factors controlling osseointegration, Q. Enumerate variou...

Q. Enumerate various factors controlling osseointegration? The factors controlling osseointegration are: i) Occlusal load ii) Biocompatibility of the material iii) Imp

Classification and features of echinodermata, Classification with its Justi...

Classification with its Justification Kingdom Animalia Animals, multi-cellular organisms with cells that lack a cell wall, many capable of movement or movement of some o

Methods of control of air pollution, The best way to maintain quality of ai...

The best way to maintain quality of air and pollutant's emissions is by using less polluting fuels and processes. Following can be taken to control air pollution. Source correc

Define methods of food processing, Define Methods of Food Processing? F...

Define Methods of Food Processing? Food is undeniably most vital to the survival of human beings. Hence, it must be processed using various scientific techniques. This is done

Clostridium perfringens infections, Clostridium perfringens infections ...

Clostridium perfringens infections Cl. perfringens is a rod-shaped, spore-bearing anaerobic organism. It is capsulated and non-motile. A characteristic feature of the organism

What is membrane, Q. What is membrane? Membrane is any delicate sheet t...

Q. What is membrane? Membrane is any delicate sheet that separates one region from another blocking or permitting completely or selectively the passage of substances. The skin,

Explain the term- ecology, What is Ecology? Ecology is the field of Bio...

What is Ecology? Ecology is the field of Biology that studies the relationship among living beings and among living beings and the environment.

What are coacervates, What are coacervates? Coarcervates are small stru...

What are coacervates? Coarcervates are small structures made of the aggregation of organic molecules under water solution. By electrical attraction the molecules join into bigg

Alzheimer’s disease research paper, Alzheimer's  disease -  a  devastating ...

Alzheimer's  disease -  a  devastating  brain  disease  which  gradually  ruins  the  ,  thinking  skills,  patient's  memory and  ultimately  the  ability  to  perform  the  simpl

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd