Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Dideoxy sequencing, Dideoxy Sequencing is the enzymatic determination and ...

Dideoxy Sequencing is the enzymatic determination and consideration of DNA or RNA sequence by the rechnique of Sanger and colleagues, based on incorporation of the chain terminati

Embryos prom synergids, Embryos Prom Synergids The synergids, which u...

Embryos Prom Synergids The synergids, which usually degenerate prior to or soon after double fertilization, are reported to give rise to embryos in Argentine mexicana, Tamari

Define the major events of the second mitotic period, Q. What are the major...

Q. What are the major events of the second mitotic period? The second mitotic period is the metaphase. In metaphase the following events occur condensed chromosomes bind in the

Define classification of carbohydrates - polysaccharides, Define classifica...

Define classification of carbohydrates - Polysaccharides? This classification is based on the number of monosaccharide units they contain, Polysaccharides are those polymers of

Explain briefly Creutzfeldt-jakob disease (cjd), Normal 0 false...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

Non-consumptive value, This is concerned more with nature's services which ...

This is concerned more with nature's services which also make vital contributions to the welfare of society and to ecological processes without which our planet would be uninhabita

Explain human fetal circulation and the adult circulation, Concerning the m...

Concerning the mixture of arterial with venous blood what is the difference between the human fetal circulation and the adult circulation? In the human fetal circulation there

Explain about the iron - micro minerals, Explain about the Iron - Micro Min...

Explain about the Iron - Micro Minerals? Iron was a familiar metal even in the ancient civilization. In India, iron implements made their appearance in between 1300-1000 BC and

State the term - localisation scales, State the term - localisation scales ...

State the term - localisation scales The localisation scales are also empirically derived, being based on studies of patients with localised brain lesions. There are frontal,

What is cell biology, What is cell biology? Cell biology is the ...

What is cell biology? Cell biology is the science of studying how cells function like as their reproduction and metabolism, their internal and external anatomy.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd