Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Parturition , P ARTURITIO N - Gestation period is of 280 days (in rab...

P ARTURITIO N - Gestation period is of 280 days (in rabbit 28 days). Parturition is the expelling of fully mature young ones from the mother's uterus. Oxytocin stimulates

State about heller nitric acid test, State about Heller's Nitric Acid Test ...

State about Heller's Nitric Acid Test Take 1 ml concentrated (fuming) nitric acid in a test tube and add 2 ml of urine by means of a pipette by the side of the test tube and la

What is telophase, What is telophase? Telophase is the cell divides apa...

What is telophase? Telophase is the cell divides apart and screws itself.

What is the lymphatic system, What is the lymphatic system? The lymphat...

What is the lymphatic system? The lymphatic system is a network of specialized valved vessels that drain interstitial fluid (lymph). The lymphatic system is also responsible fo

Zoology, find the habits and habitats of scyphas?

find the habits and habitats of scyphas?

Endocrine glands, Endocrine glands Endocrine glands have no ducts - ...

Endocrine glands Endocrine glands have no ducts - so these are also called as ductless glands Eg.Pituitary etc., These glands secrete chemical substances called HORMONES

Kind of tetrasporic embruo sac, what are the kinds of tetrasporic embryo sa...

what are the kinds of tetrasporic embryo sac...detail information

Process of respiration, Process of Respiration Respiratory and Circul...

Process of Respiration Respiratory and Circulator System Gaseous exchange that is intake of oxygen and output of carbon dioxide, takes place at the respiratory surface since

Flow cytometry, Flow cytometry is an analysis of biological material by de...

Flow cytometry is an analysis of biological material by detection of light- absorbing or fluorescing properties of cells or subcellular fractions (that is chromosomes) passing in

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd