Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

What is triacylglycerols, A triglyceride TG, TAG, triacylglycerol or triacy...

A triglyceride TG, TAG, triacylglycerol or triacylglyceride is an ester derivative from glycerol and three fatty acids. There are various triglycerides: depending on the oil source

General protocol for media preparation, General Protocol for Media Preparat...

General Protocol for Media Preparation A general protocol for media preparation is as follows: 1. Prepare stock solutions one day before the medium is to be made. 2. Wei

Hydrophilicity plot, Hydrophilicity Plot is a computer plot which checks t...

Hydrophilicity Plot is a computer plot which checks the relative summed hyrophobicity or hydrophilicity of adjacent amino acid sidechains (usually within a moving window of about

How do the repairing enzymes of the genetic system act, How do the repairin...

How do the repairing enzymes of the genetic system act? There are enzymes inside the cells that detect errors or alterations in DNA molecules and begin a repair of those errors

Chromosomes and chromatin strands are present in stage, Drosophila has 4 bi...

Drosophila has 4 bivalents (homologous chromosomes) formed at Meiosis I. How many chromosomes and chromatin strands are present in each of the following stages- Anaphase of mito

Spirogyra, whats the meaning of asexual reproduction

whats the meaning of asexual reproduction

Explain echinocandins, Explain Echinocandins It inhibit synthesis of β ...

Explain Echinocandins It inhibit synthesis of β (1,3)-D-glucan, an essential component of the fungal cell wall. The potential for adverse effects in humans is low because of th

Involution - internalization of mesoderm, Involution - Internalization of M...

Involution - Internalization of Mesoderm As by now mentioned, in the frog Xenopus (and probably in other amphibian species as well) the cells of presumptive mesoderm are in t

Protozoa., brief account on classification and general characters of protoz...

brief account on classification and general characters of protozoa

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd