Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Explain about the holmgren''s wools, Explain about the Holmgren's  Wools  ...

Explain about the Holmgren's  Wools   This is a matching test  of  coloured pieces of  wool. While this  is not  a highly  favored method  of  testing  it does  show  serious d

What are the five kingdoms, Q. What are the five kingdoms into which living...

Q. What are the five kingdoms into which living beings are divided? And which group of living being is out of this classification? The five kingdoms of living beings are the ki

How are lipids used as an energy source by the organism, How are lipids use...

How are lipids used as an energy source by the organism? Carbohydrates are the major energy source for aerobic cell respiration. In the absence or deficiency of such substances

Define the food sources of thiamin, Define the Food Sources of Thiamin? ...

Define the Food Sources of Thiamin? Thiamin is present in many food products and depending on the amount of vitamin present, we have categorized the foods as rich, good or fair

Define peri-implantitis, What is peri-implantitis? Peri-implantitis as ...

What is peri-implantitis? Peri-implantitis as defined by Meffert is the progressive loss of peri-implant bone as well as soft tissue inflammatory changes. Bacterial invasion of

Parasympathetic discharge to the heart leads to, An enhance in parasympathe...

An enhance in parasympathetic discharge to the heart leads to A. An enhance in the conductance of F-channels in SA node cells. B. An enhance in the conductance of potassium

Causes of cancer, Causes of Cancer Scientists have identified the cellu...

Causes of Cancer Scientists have identified the cellular genes that code for those proteins which jointly control and regulate cell growth and division. These  genes are of two

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd