Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Weight of plants - quantitative characters, Weight of Plants - Quantitative...

Weight of Plants - Quantitative Characters Weight is one of the most important quantitative characteristics of plants. Quantitatively growth is best measured on the basis of d

Isolating mechanism, In this section we are to discuss the means by which p...

In this section we are to discuss the means by which populations get separated or isolated from each other, first gain the status of'Sub-species and finally evolve mechanisms which

Lungs - respiration, Lungs - Respiration Lungs can be simple, characte...

Lungs - Respiration Lungs can be simple, characterised by air exchange with surrounding environment by diffusion only. These are called the diffusion lungs and are present in

Venous return, This is the amount of blood that is returned to the heart by...

This is the amount of blood that is returned to the heart by the veins. This is influenced by various factors. Inspiration decreases the pressure in the  central veins and thus inc

Define traditional cycle of root canal treatment, Define Traditional Cycle ...

Define Traditional Cycle of Root Canal Treatment The traditional cycle of Root Canal Treatment a) Dig in the tooth to make a big hole b) Then, look through this hole to f

Define types of root canal perforations according to causes, Define Types o...

Define Types of Root Canal Perforations According To Causes Iatrogenic causes. Pathological causes.

Define hormonal imbalance as a factor for obesity, Define Hormonal imbalanc...

Define Hormonal imbalance as a factor for obesity? Certain diseases associated with secretion of hormones, e.g., hypothyroidism, hypogonadism and Cushing's syndrome exhibit obe

What do you mean by recovery period, Q. What do you mean by Recovery Period...

Q. What do you mean by Recovery Period? At the instant exercise is discontinued, the ECG recorded is turned on and left running for a few seconds while the blood pressure is re

Coordination and response, Name the two hormones produced by the pancreas a...

Name the two hormones produced by the pancreas ans say in what circumstances, in what way, they adjust the glucose concentration in the blood.

Nature of light - floral induction, Nature of Light - Floral Induction ...

Nature of Light - Floral Induction Red light promotes flowering in short day plants. If the dark regime of a short day plant is interrupted by red light, flowering is inhibite

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd