Define vitamin k-dependent carboxylation, Biology

Assignment Help:

Define Vitamin K-dependent carboxylation?

Vitamin K acts as a cofactor in the synthesis of g-carboxyglutamic acid (Gla) from glutamic acid residues required for the normal coagulation of blood. Figure here also illustrates the vitamin K cycle.

593_Vitamin K-dependent carboxylation.png

The biological role of vitamin K, therefore, is to act as a cofactor for a specific carboxylation reaction that transforms selective glutamate (Glu) residues to g- carboxyglutamate (Gla) residues. The reaction is catalyzed by a microsomal enzyme, g-glutamyl, or vitamin K-dependent carboxylase, which in turn is linked to a cyclic salvage pathway known as the vitamin K epoxide cycle. The hydroquinone (reduced form of vitamin K), COP and 02 are required for the reaction. During the catalysis, hydroquinone is oxidized to vitamin K 2,3-epoxide and the energy derived from the  oxidation drives the carboxylation.


Related Discussions:- Define vitamin k-dependent carboxylation

Diagnosis of diabetes mellitus, Q. Diagnosis of diabetes mellitus? Time...

Q. Diagnosis of diabetes mellitus? Timely and proper diagnosis plays a key role not only in identifying new cases but also in managing old cases with or without diabetic compli

Define excretion of iron in human body, Define Excretion of Iron in Human B...

Define Excretion of Iron in Human Body? Our body has a limited capacity to excrete iron once it has been absorbed. Daily losses in adult man are between 0.9 to 1.05 mg. About 0

Illustrate about whey protein, Illustrate about Whey protein Whey prote...

Illustrate about Whey protein Whey protein concentrate (WPC) is a highly nutritious ingredient manufactured from fresh dairy whey and it is spray dried to provide an excellent

BIOLOGY, 100 WORDS NOT COMPLETED

100 WORDS NOT COMPLETED

The advantages of human milk over cow milk, a) What are the advantages of h...

a) What are the advantages of human milk over cows' milk for feeding babies? b) Apart from the composition of the milk, what are the other advantages of breast- feeding?

Growth and development of plants, Growth and Development of Plants You...

Growth and Development of Plants You must have seen beautiful plants growing in pots in a garden. The plant grows while the pot does not. As a rule living things grow, but non

Selenium, S e l e n i u m Selenium toxicity due to pollution of ...

S e l e n i u m Selenium toxicity due to pollution of environment has been reported in animals. Contamination of pasture from industries emitting fly ash particularly fo

What are the major biological processes, Q. What are the major biological p...

Q. What are the major biological processes in which calcium participates? Calcium is present in approximately all cells and has various functions. Calcium has an significant ro

Explain about the vascular tissues, Is transportation of gases in tracheoph...

Is transportation of gases in tracheophytes made through the vascular tissues? Carbon dioxide and oxygen are not transported by the xylem or phloem. These gases reach the cells

Prevent and control staphylococcal food poisoning, To prevent and control S...

To prevent and control Staphylococcal food poisoning: • Avoid contamination of foods • Kill organism by heating, refrigeration • Personnel hygiene • Adequate cookin

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd