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Modulation of the transcription of cell cycle proteins?
The 1,25-(OH),D compound (calcitriol), is present in the blood complexes to the vitamin D-binding protein, a specific a-globulin. Calcitriol is believed to act on target cells in a similar way to a steroid hormone. Free hormone crosses the plasma membrane and interacts with a specific nuclear receptor known as the vitamin D receptor, a DNA-binding, zinc-finger protein with a relative molecular mass of 55,000. This ligand-receptor complex binds to a specific vitamin D-responsive element and, with associated transcription factors (e.g. retinoid X receptor), enhances transcription of mRNAs which code for calcium-transporting proteins, bone matrix proteins, or cell cycle-regulating proteins.
tube feet,stone canal,medreporite and teidman;s body notes
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Notes on branches of embryology
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