Define low - density lipoprotein, Biology

Assignment Help:

Q. Define Low - density lipoprotein?

Ans.

LDL is the major cholesterol-rich lipoprotein carrying approximately 70 per cent of plasma cholesterol. It serves to transport cholesterol to peripheral cells.

The Nobel laureates Brown and Goldstein identified the LDL receptor that recognizes apoprotein B100 of LDL particles (Brown and Goldstein, 1986). The receptors are large glycoproteins situated on the surface of cells in specialized areas termed coated pits. Coated pits are organelles necessary for the internalization of macromolecules. The LDL receptor gene has been cloned and localized to the short arm of chromosome 19.

The clinical relevance of this structural detail of the receptor will be appreciated when the inborn error of cholesterol metabolism called familial hypercholesterolaemia is discussed. In this condition there are defects in the gene coding for the receptor.


Related Discussions:- Define low - density lipoprotein

Is reproduction in sponges asexual or sexual, Q. Is reproduction in sponges...

Q. Is reproduction in sponges asexual or sexual? Reproduction in sponges can be asexual by budding, fragmentation or gemmation (regeneration) or sexual with larval stage a cili

Carbon cycle, Carbon is important constituents of all organic compounds. It...

Carbon is important constituents of all organic compounds. It forms 49% of dry weight of the organisms.  Earth atmosphere contains 0.03% carbon dioxide gas.               The c

Determine the enzymatic chemical reactions, How does facilitated diffusion ...

How does facilitated diffusion present similarities with enzymatic chemical reactions? One of the main examples of facilitated transport is the entrance of glucose from the blo

Plants and animals - biological weathering, Plants and animals The acti...

Plants and animals The activity of living organisms like lichens, fungi, bacteria, blue green algae, bryophytes is also responsible for weathering.  It is referred to as biolog

Build a genomic dna library, Construct a genomic DNA library with the help...

Construct a genomic DNA library with the help of some methylaee and finall do viral packaging.

Show subkingdoms into which the plant kingdom is divided, Q. What are the s...

Q. What are the subkingdoms into which the plant kingdom is divided? The kingdom Plantae is divided into two big subkingdoms: the tracheophytes and the bryophytes (gymnosperms,

Define nutritional needs during pregnancy, Define Nutritional Needs during ...

Define Nutritional Needs during Pregnancy? It must be evident by now that several physiological changes occur in the body of an expectant mother and that malnutrition can' adve

Difference between cerebrum and brain, Q. What is the difference between ce...

Q. What is the difference between cerebrum and brain? What are the major parts of these structures? The concept of brain or encephalon comprehends the cerebrum mostly referred

What are the antigens and antibodies of abo blood system, What are the anti...

What are the antigens and antibodies of each blood type of the ABO blood system? Type A: antigen A, antibody anti-B. Type B: antigen B, antibody anti-A. Type AB: antigens A and

Digestion of proteins, Digestion  of proteins Digestion  of proteins  ...

Digestion  of proteins Digestion  of proteins  is  initiated  in  the  stomach by pepsin.  Pepsin  acts upon food proteins  and  converts them  to proteoses  and  peptones whic

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd