Define low - density lipoprotein, Biology

Assignment Help:

Q. Define Low - density lipoprotein?

Ans.

LDL is the major cholesterol-rich lipoprotein carrying approximately 70 per cent of plasma cholesterol. It serves to transport cholesterol to peripheral cells.

The Nobel laureates Brown and Goldstein identified the LDL receptor that recognizes apoprotein B100 of LDL particles (Brown and Goldstein, 1986). The receptors are large glycoproteins situated on the surface of cells in specialized areas termed coated pits. Coated pits are organelles necessary for the internalization of macromolecules. The LDL receptor gene has been cloned and localized to the short arm of chromosome 19.

The clinical relevance of this structural detail of the receptor will be appreciated when the inborn error of cholesterol metabolism called familial hypercholesterolaemia is discussed. In this condition there are defects in the gene coding for the receptor.


Related Discussions:- Define low - density lipoprotein

Advice on dischargeperi operative problems, Advice on Discharge :  Patient...

Advice on Discharge :  Patients are allowed to go home on 8th or 9th day. It could be even earlier after off pump coronary artery surgery (OPCAB). They should gradually increase t

Radial cleavage - metazoa, Radial cleavage - Metazoa Radial cleavage p...

Radial cleavage - Metazoa Radial cleavage produces tiers or layers of cells one on top of another. Radial cleavage is also said to be indeterminate or regulative because each

What are the main symptoms of the pulmonary, What are the main symptoms of ...

What are the main symptoms of the pulmonary and of the intestinal phases of the ascaris infestation? In the pulmonary stage the ascaris infestation causes cough, hemoptysis, dy

Explain the scaling from individuals to ecosystems, Explain the Scaling fro...

Explain the Scaling from individuals to Ecosystems? Models that explain how individual organisms acquire energy and materials, and how they use them for survival, growth and re

What are the reproductive novelties, Q Do beings of the class Reptilia have...

Q Do beings of the class Reptilia have indirect or direct development? In beings of the class Reptilia the embryonic development is direct. So there is no larval stage. Q.

Explain the basic concept of energy, Explain the basic Concept of Energy? ...

Explain the basic Concept of Energy? Energy in simple terms may be defined as the ability, or power, to do work. As a student of dietetics and nutrition, you already know that

Can diseases be etiological factor for diabetes, Q. Can Diseases be etiolog...

Q. Can Diseases be etiological factor for diabetes? Diseases: In aging, a very important cause of diabetes could be an underlying disease. Diabetes occurs secondary lo some ot

Mycroboilogy mycoplasma, How we write assimgment about mycobiology of mycop...

How we write assimgment about mycobiology of mycoplasma in detail

What is interdental threaded cleaners, What is Interdental Threaded Cleaner...

What is Interdental Threaded Cleaners The use of floss is recommended around any implant-supported bridge, crown, or bar. Instruct the patient to wrap the floss around the impl

What are the conventional signs used in genetic family trees, What are the ...

What are the main conventional symbols and signs used in genetic family trees? In genetic family trees the male sex is usually shown by a square and the female by a circle. Cro

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd