Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Psychedelic drugs (hallucinogens), PSYCHEDELI C DRUGS (HALLUCINOGENS) - ...

PSYCHEDELI C DRUGS (HALLUCINOGENS) - They act mainly on CNS and greatly alter one's thoughts, feelings and perceptions, called psychedelic drugs. They cause optical or a

Hypothermia, Hypothermia As the blood passes through the oxygenato...

Hypothermia As the blood passes through the oxygenator, hypothermia machine allows the blood to cool to the required temperature. Generally, the temperature is brought dow

Parasympathetic discharge to the heart leads to, An enhance in parasympathe...

An enhance in parasympathetic discharge to the heart leads to A. An enhance in the conductance of F-channels in SA node cells. B. An enhance in the conductance of potassium

Difference between the exocrine and endocrine gland, Q. What is the differe...

Q. What is the difference between the exocrine gland and the endocrine gland? Endocrine gland is a gland whose secretions are called as hormones that are collected by the blood

Determine when the homologous chromosomes occur, In which period of meiosis...

In which period of meiosis does the pairing of homologous chromosomes occur? The pairing of homologous chromosomes is an essential step for meiosis because the rightness of the

Structure of water, STRUCTURE OF WATER It may interest you to know that w...

STRUCTURE OF WATER It may interest you to know that water is a universal solvent and is a major constituent of all living organisms. Earth is the only planet where water exists i

What is the dna vaccine, Q. What is the DNA vaccine? The DNA vaccinatio...

Q. What is the DNA vaccine? The DNA vaccination or is a vaccination technology based on genetic engineering. In DNA vaccine a recombinant plasmid (vector) containing the gene o

What is the life duration of the red blood cells, Q. On average what is the...

Q. On average what is the life duration of the red blood cells? Where are they destroyed? What is the destination of the heme groups after the destruction of hemoglobin molecules?

What is supraventricular arrhythmias, Q. What is Supraventricular Arrhythmi...

Q. What is Supraventricular Arrhythmias? Such arrhythmia tend to be reduced by the vagal withdrawal accompanying the onset of exercise.This and wandering pacemakers tend to rec

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd