Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Define the meaning of population structure, Define the meaning of Populatio...

Define the meaning of Population Structure? The structure of population can be viewed as to how the population is composed of in terms of age and sex. The structure of populati

What are steroid hormones , Cholesterol is the precursor of the five major...

Cholesterol is the precursor of the five major classes of steroid hormones.The synthesis of steroid hormones is initiated by the removal of a six-carbon unit  from  carbon  20  of

Phylum annelida, PHYLUM ANNELIDA Definition  and Introduction Bila...

PHYLUM ANNELIDA Definition  and Introduction Bilateral and  protosomial  eucoelomate  eumetazoans  whose  long   narrow and  wormlike body  is division  into  ring like  t

Explain about the terms - bursae and captacula, Explain about the terms - b...

Explain about the terms - bursae and captacula? Paired water-filled sac located at base of each arm of a brittle star. Cilia in bursae circulate water. Its surface is significa

Weaning the infant from the incubator, Weaning the Infant from the Incuba...

Weaning the Infant from the Incubator When heater output reading is minimal or nil it suggest that infant is capable of generating enough metabolic heat to keep himself war

Explain xanthan gum, Explain Xanthan Gum Xanthan gum is a microbial pol...

Explain Xanthan Gum Xanthan gum is a microbial polymer prepared commercially in pure culture fermentation from Xanthomonas campestris. This polysaccharide was given the generic

Massaging and tumbling techniques in meat products, M a s s a g i n ...

M a s s a g i n g and tumbling techniques To improve the desirable characteristics of meat products massaging and tumbling techniques were developed. Massaging involves

Deficiency diseases-phosphorus deficiency, Phosphorus deficiency Defici...

Phosphorus deficiency Deficiency of phosphorus is usually primary and is widespread under natural conditions. It is characterized by pica, poor growth, infertility, and osteody

Crab, What are the excretory organs of crab

What are the excretory organs of crab

Theory of pangenesis, THEO R Y OF PANGENESIS - To make up the weaknes...

THEO R Y OF PANGENESIS - To make up the weakness of inheritance Darwin in this theory assumed the existence of Pangenes (gem mules) as small units (representives) of each par

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd