Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Agro industrial-chopping and grinding, Chopping/grinding These are the ...

Chopping/grinding These are the processes by which the particle size of cereals, oil cakes and roughages including green fodders and crop residues is reduced employing various

Reproduction, What is the difference between asexual and sexual reproductio...

What is the difference between asexual and sexual reproduction

How can you describe the homeostasis, Q. What is the homeostasis? What are ...

Q. What is the homeostasis? What are the sensors, effectors and controllers of homeostasis? Homeostasis comprises the processes by which the organism maintains extracellular an

Principles of haccp, Principles of HACCP A) Determine the  Critical  Co...

Principles of HACCP A) Determine the  Critical  Control  Points  (CCPs) B) Establish  Critical Limit(s) C) Establish a  System  to  Monitor Control of the  CCP D) Esta

Assignment, Write short note onApplications of apical dominance in horticul...

Write short note onApplications of apical dominance in horticulture and agriculture

Explain circulatory support and types of shock, Explain circulatory support...

Explain circulatory support and types of shock? CIRCULATORY SUPPORT 1) A "shock" state is characterised by hypoperfusion of tissue and cellular hypoxia. Circulatory suppo

Examples of genetic engineering that are improve crop plant, Give three exa...

Give three examples of genetic engineering that are intended to improve crop plants. Genetic engineering of crop plants can improve resistance to pests, retard ripening, impro

Explain in brief about the ciliary muscle, Explain in brief about the cilia...

Explain in brief about the ciliary muscle During accommodation the ciliary muscle contracts and in turn the size of the ciliary ring is reduced. This results in the suspensory

Factors influencing rs content -amylose or amylopectiz ratio, Explain the F...

Explain the Factors Influencing RS Content -Amylose or Amylopectiz ratio? Amylose/Amylopectirz ratio: In general, foods containing high amylose/amylopectin ratio lead to higher

Explain the manifestations of iron deficiency anaemia, Explain the Manifest...

Explain the Manifestations of Iron Deficiency Anaemia? • Paleness of conjunctiva • Paleness of tongue • Paleness of mucosa of soft palate • Low haemoglobin • Swelling of

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd