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Define Effect of feeding method on drug availability?
The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.
Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.
XYY humans are fertile males. XXX humans are fertile females. What do these observations reveal about the mechanisms of sex determination and dosage compensation?
Fertilization - Pre-Embryonic Development Ovulation generally takes place between 9th to 14th day after the end of last menstrual period. Fertilization of oocyte initiates dev
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Elaborate the term - Gill slits. Lateral opening in the wall of pharynx which allows water to enter into mouth and exit through the pharynx. This is one of the ancestral charac
FLUI D MOSAIC MODEL Proposed by Nicholson and Singer (1972) Proteins and lipids are arranged in a mosaic fashion. Lipids and proteins are in a semi fluid structure.
What is the role of primary consumers in a food chain? Give an example of a primary consumer in a terrestrial and an aquatic ecosystem.
Main Components of Blood Plasma You would recall the various types of cells found in blood. The composition of human blood plasma is given in Table. The very structure of bloo
wich variables are controlled when conducting a phototropism experiment
Light Stratification - Lake Ecosystem The penetration of light in water bodies is limited depending on the transparency of water and its ability to absorb light. On the basis
MCNAUGHTON'S CASE AND LAW: In 1843, McNaughton shot and killed Sir Robert Peel's secretary Edward -Drymmond. It was shown that McNaughton suffered from a number of delusi
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