Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Human anatomy-physiology , Human anatomy: Human anatomy is a branch of bio...

Human anatomy: Human anatomy is a branch of biology which, with deals with human physiology and biochemistry. It is mainly concerned with the scientific study of the internal stru

Define nutritional support management for chemotherapy, Define Nutritional ...

Define Nutritional Support Management for chemotherapy? Antiemetics are used in the treatment of chemotherapy induced nausea and vomiting. Antiemetics become absolutely necessa

Baby delivery, some deliveries of baby occur early na. y is it so?

some deliveries of baby occur early na. y is it so?

Theories to explain fine structure of chromosome, THEORIES TO EXPLAIN FINE ...

THEORIES TO EXPLAIN FINE STRUCTURE OF CHROMOSOME (1 ) Multistranded theory Steffenson 1959 - each chromosome composed of two chromatids (Half Chromosome) and each chromat

Determine the diversity of biological evolution, Is crossing over important...

Is crossing over important for the diversity of biological evolution? Sexual reproduction and recombination of linked genes (crossing over) are, with mutations, the main instru

Methods of virus, How Viruses Multiply? Obligatory parasitism - Outsi...

How Viruses Multiply? Obligatory parasitism - Outside cells viruses are nonliving, inactive   particles but after entering into live cells these multiply fast by replication

Concept of nursing unit, CONCEPT OF NURSING UNIT: Concept in the desig...

CONCEPT OF NURSING UNIT: Concept in the design and facilities of nursing unit has been changed time to time based on the different categories of patients and peculiarities of

Describe the functional problems of implant failures, Functional Problems o...

Functional Problems of implant failures The masticatory efficiency of the implant supported prosthesis depends on the anchorage related factors and the prosthesis related fact

Excretory system - kidney, Kidney - 2 in number. Dark red. Sl...

Kidney - 2 in number. Dark red. Slightly flattened. Bean shaped. 10 cm. long, 5 cm wide and 4 cm thick (In rabbit 20-25 mm). Weighing 150 gm in male 135 gm in fema

Explain autoxidation, Autoxidation It is generally agreed that "autoxid...

Autoxidation It is generally agreed that "autoxidation", that is, the reaction with molecular oxygen via a self - catalytic mechanism, is the main reaction involved  in oxidati

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd