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Define Effect of feeding method on drug availability?
The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.
Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.
Why is complementary base pairing important in DNA structure? Complementary base pairing is important because the hydrogen bonds between the bases hold the two strands of DNA
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biological significant of a skeleton
- Nuclear membrane disorganize at the beginning of this phase. - Spindle fibers originate and the kinetochore fibers attach to the kinetochore of homologous chromosomes from eac
What is the Speech Perception Test The subject is asked to listen to a series of 60 sounds, each of which consists of a double e digraph with varying prefixes and suffixes. The
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