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Define Effect of feeding method on drug availability?
The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.
Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.
What is the difference among white and red blood cells? What are leukocytes? Red blood cells are erythrocytes and white blood cells are the leukocytes. Leukocytes are cells
Stability studies are req. for the product stable at their desire time as per specification , which give the expiry date and quality as per the manner.
Estimate the Results of Tetralogy of Fallot? In excellent centres, the mortality is reported one per cent or less. In infants and babies with low weight, higher mortality is ex
Can you help explain this question in fairly simple terminology? A certain sample of DNA has a Tm of 65oC, while another has a Tm of 58oC. What can you tell about the relative n
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Bacteria: Bacteria have a protective covering called 'cell wall'. Beneath this. there is a plasma membrane which encloses protoplasm of the bacterium containing various types
Characteristic features of Phylum Cnidaria All are aquatic animals. Radial or biradial symmetry around an oro-aboral axis, but no head. Diploblastic, with an epidermi
Functional Problems of implant failures The masticatory efficiency of the implant supported prosthesis depends on the anchorage related factors and the prosthesis related fact
Protein structure is determined solely by a protein amino acid sequence. Should a genetically engineered protein in which the order of all amino acids is reversed therefore have th
The left coronary artery arises from the left posterior aortic sinus. It runs to the left behind the pulmonary trunk and appears between left auricle and pulmonary trunk. In that p
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