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Define Effect of feeding method on drug availability?
The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.
Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.
Define the V2 receptor antagonist A new drug named ANTI-V2R has been developed that is a V2 receptor antagonist. When ANTI-V2R binds to a V2 receptor, there is no binding of v
Determine the extracellular concentration of TVA Consider Neuron B in the frog central nervous system whose plasma membrane has a previously unknown channel that is selectivel
Describe in detail about the chlorophyll molecule Each chlorophyll molecule contains magnesium ion, there could be no green plants without magnesium. As magnesium is present in
Q. What is the heterophagic intracellular digestion and How is this process accomplished? Heterophagic intracellular digestion is the breaking into smaller substances of extern
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Fructose-1,6-bisphosphate and Fructose-6-phosphate : The conversion of fructose-1,6- bisphosphate to fructose-6-phosphate is catalysed by fluctose-1,6-bisphosphatase which i
Define Precaution for Separation of Amino Acids by Paper Chromatography? 1. Hold the paper with the extra strip kept at one side. Handling of whatman paper with hand should be
One can verify the age of an oak tree by counting the annual rings of formed by the. a. primary xylem, apical meristem b. secondary phloem, vascular cambium c. dermal
Nocardiosis Nocardiae are aerobic, saprophytic, gram-positive, partially acid-fast filamentous bacteria. Currently, there are 30 species included within the genus. Members of
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