Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Hormones secreted by adrenal gland, Hormone s . Cortical steroids (cortico...

Hormone s . Cortical steroids (corticoids-hormones of adrenal cortex) are grouped into three catagories : mineralocorticoids, glucocorticoids and gonadocorticoids. (i) Mine

Respiration.., different types of respiration system in different organisms...

different types of respiration system in different organisms

Procedures for diagnosis - epidemiological data , Procedures for diagnosis ...

Procedures for diagnosis Epidemiological data:   The epidemiological information with regard to the history, symptoms, morbidity, mortality, seasonality, age, sex, breed and spe

Explain citric acid cycle, Explain citric acid cycle In  the citric aci...

Explain citric acid cycle In  the citric acid cycle, the oxaloacetate is first condensed with acetyl CoA, and  then regenerated  as  the cycle  is  comp!eted.  But these  react

What is phagocytosis and phagosomes?, Protozoans ingest food by phagocytosi...

Protozoans ingest food by phagocytosis, and consequently, the ingested food is surrounded by a plasma membrane creating a food vacuole, or phagosome. Digestion does not start until

How is the circulatory system of birds characterized, How is the circulator...

How is the circulatory system of birds characterized? Birds, as every vertebrate, have a closed circulatory system. The heart is same to the mammalian heart, having four chambe

Polar bear is adapted to its environment, Give three ways in which a polar ...

Give three ways in which a polar bear is adapted to its environment. A polar bear is adapted to its environment by its high ratio of bulk to surface area, a thick water-repelle

Determine about the prokaryotes and eukaryote cell, Determine about the pr...

Determine about the prokaryotes and eukaryote cell The eukaryotic cells, on the other hand, have a true nucleus wherein the genetic material, DNA is enclosed within a well-def

Define type of root canal perforations according to location, Define Types ...

Define Types of Root Canal Perforations According to location According to location (level) in relation to crestal bone): Coronal perforation: (supragingival) coronal to

What is severity of the oesophagitis, Q. What is severity of the oesophagit...

Q. What is severity of the oesophagitis? The severity of the oesophagitis resulting from oesophageal reflux is determined by the content of gastric reflux mucosal resistance,

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd