Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Define efficiency - terminologies used in chromatography, Define Efficiency...

Define Efficiency - terminologies used in chromatography? Efficiency in chromatography is expressed as number of theoretical plates.           H =   L/N Where, H is heigh

Explain the requirements of special stains, Explain the requirements of Spe...

Explain the requirements of Special Stains? Special stains are required to make spores clearly visible. Different techniques like negative staining, dorner staining method, sch

Define the nutritional assessment methods, Define the Nutritional assessmen...

Define the Nutritional assessment methods? Nutritional assessment methods commonly used are enumerated herewith. 1. Bodyweight measurement s remain to be the most practical

What are the cytochromes, Q. What are the cytochromes? Cytochromes are ...

Q. What are the cytochromes? Cytochromes are proteins of the interior mitochondrial membrane that are specialized in electron transfer and participate in the respiratory chain.

What is tricuspid atresia: surgery for single ventricle, What is Tricuspid ...

What is Tricuspid Atresia: Surgery for Single Ventricle Physiology In tricuspid atresia, the right atrium fails to open into right ventricle through a right atrioventricular va

Determine the implant insertion, Implant insertion The technique for in...

Implant insertion The technique for insertion of the implant depends largely upon the system being used. In general, the final bone preparation site diameter is slightly smalle

State the term - infection, State the term - Infection Infection is th...

State the term - Infection Infection is the invasion of the body by disease-producing (pathogenic) microorganisms and the reaction of the tissues to their presence and to the

Determine health hazards associated with high altitude, Determine Health Ha...

Determine Health Hazards Associated with High Altitude? Abrupt exposure to altitudes greater than 10,000 ft (3050 in) elevation is frequently associated with symptoins of altit

What are called transactions, What are called Transactions? The grouped...

What are called Transactions? The grouped SQL statements are known as Transactions (or) A transaction is a collection of actions embused with ACID properties.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd