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Define Effect of feeding method on drug availability?
The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.
Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.
Why doesn't gene therapy cure cystic fibrosis? Although a normal gene is introduced into a patient's surface cells in the lung, these cells are not the ones that require produc
Define Procedure for Detection of Number of Bacteria in Milk? 1. Place a clean, non-greasy slide over the graph paper. 2. Spread 0.01 ml of the milk over an area of 1 cm2 as
Aeration is the process on which water and air come into contact. It is carried out by spraying water in the form of spray or fountain over air. Aeration achieves the following obj
List the types of Gellan gum. The three types of gellan gums are: High acetyl gellan (partially deacetylated) Low acetyl gellan (highly deacetylated) High cl
Q. Why is the concept of a single gene as ultimateunit of inheritance inadequate to provide a unitary explanation for protein synthesis, recombination and mutation? Answer:
mode of nutrition in rose plant
a) How do copper and hormone releasing IUDs act as contraceptives? Describe. b) If you squeeze a seed of orange you may be observe many embryos of different sizes. How is it
Define Functions of Inorganic Phosphorus? The major functions of inorganic phosphorus include: a) Structural component of bones and teeth: Phosphorus is a part of calcium ph
Define need of vitamin C during pregnancy period? Vitamin C deficiency has not been shown to affect the course or outcome of pregnancy in humans, although low plasma levels hav
Phyium Oomycetes 1) They reproduced asexually by non-motile conidia and/or mobile flagellatedzoospores. 2) The sexual reproduction is by fusion of a male gamete with an egg
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