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Define Effect of feeding method on drug availability?
The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.
Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.
Nutrition of Embryo Sac The morphology of the ovule suggests that the chalazal end is the main route for the entry of nutrients. The funicular vascular supply ends at the bas
Q. What do you know by Hemodynamic Responses? Reduced exercise capacity roughly reflects impaired LV function, and may contribute its prognostic value to this association. Comp
excretory organs of protozoa
Outline the steps involved in using bacteria to produce human insulin. The gene for insulin is 'cut' from the appropriate strand of DNA using restriction enzymes. Plasmids are
habitat, habit, cell wall chemistry, reason why cell wall like this of Archaebacteria , eubacteria,fungi,algae,bryophytes ,pteridophyes, gymnosperms , angiosperms..
Explain Pro-Oxidants Transition metals, particularly those possessing two or more valency states and a suitable oxidation - reduction potential between them (e.g., cobalt, cop
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Explain the Determination of Hydrolysis Hydrolysis of calcium pantothenate in acidic medium produces α,γ-dihydroxy-β,β-dimethylbutyrolactone, which reacts with hydroxylamine i
Pituitary The pituitary is also known as hypophysis. It is composed of two embryologically distinct tissue. The anterior pituitary or adenohypophysis is derived from the roof
Determine the Muscular-Skeletal System It is known we all do movement and these take place by movement of muscles in coordination with the skeletal system. In human body muscle
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