Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Process of conducting system of the heart, Impulses reaching the AV node fr...

Impulses reaching the AV node from the atria are delayed a little as they pass through the trunk and crura. The impulses first reach the papillary muscles and their contraction clo

What are his morning and bedtime doses, a) Donald is a 50 year old male wit...

a) Donald is a 50 year old male with a long history of bipolar disorder. He has been hospitalized three times in the last 8 months for manic episodes. He was just admitted to your

Xerophytes, Ask question #Mcharacteristics of xerophytesinimum 100 words ac...

Ask question #Mcharacteristics of xerophytesinimum 100 words accepted#

What is physiologic adaptation, Physiologic Adaptation Modeling is a su...

Physiologic Adaptation Modeling is a surface specific activity (apposition or resorption) that produces a net change in the size and/or shape of the bone. It is an uncoupled pr

Explain about the gelation, Explain about the Gelation? Gelation refers...

Explain about the Gelation? Gelation refers to the process where denatured molecules aggregate to form an ordered protein network. Proteins can form a well-ordered gel matrix b

Termination of rna, Transcription   continues   until a termination   serie...

Transcription   continues   until a termination   series   is reached.   The most common termination signal is a GC-rich region which is a palindrome, followed by an AT-rich sequen

Define national iodine deficiency disorder control programme, Define Nation...

Define National Iodine Deficiency Disorder Control Programme (NIDDCP)? The prevalence of iodine deficiency disorders (IDD) are seen more among adolescent's young adults and sc

Difference between ulcerative colitis and crohns disease, What is the diffe...

What is the difference between ulcerative colitis and Crohn's disease? The differences between the two include: I) Anatomic distribution of the inflammatory process: Crohn'

Explain oligosaccharides, Oligosaccharides Compounds containing 2 to 6 ...

Oligosaccharides Compounds containing 2 to 6 monosaccharides units joined by a glycosidic  linkage.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd