Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

What is nervous system, What is Nervous System? The nervous system is m...

What is Nervous System? The nervous system is made up of associations of cells called neurons. Bundles of neurons are called nerves. The nervous system is divided into two part

Attributes of population, Attributes of Population The attributes of a ...

Attributes of Population The attributes of a population are of two basic types : i) Numerical attributes such as density, mortality (birth rate), mortality (death rate), disper

What cells produce the pigment in hair, 1.How does the skin on your palm di...

1.How does the skin on your palm differ from that on the back (posterior) of your hand? 2.Describe the differences observed in the type and distribution of hair on the front (anter

Illustrate the term - digestive caecum., Illustrate the term - Digestive ca...

Illustrate the term - Digestive caecum. A blind-ended pouch which extends from main digestive tract. Digestive ceca may be the sites for final digestion of ingested food or may

Active instruments-small occlusal, Active instruments -This category o...

Active instruments -This category of instruments actively engage a restorative , enabling a specific dislodgment force to potentially lift off the prosthesis -These devices

Difference between anaerobic and aerobic beings, Q. What is the difference ...

Q. What is the difference between anaerobic and aerobic beings? Anaerobic organisms are those that live or can live under oxygen-lacking environments and Aerobic organisms are

Prevention of iron deficient anaemia, Prevention   You as nurse needs t...

Prevention   You as nurse needs to ensure that iron supplementation  is given to children who are at risk for iron deficiency.  Iron supplementation  should start between 4 and

Explain the sa node cardiac muscle cells, Which of the following is true fo...

Which of the following is true for SA node cardiac muscle cells? A. An increase in the binding of norepinephrine to beta-adrenergic receptors in SA node cells will lead to an i

Zoology, classification mollusca

classification mollusca

nutrient stability as affected by processing of feeds, Nutrient stability ...

Nutrient stability as affected by processing of feeds Nutrient stability under normal conditions of storage and processing is one of the important factors determining the effe

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd