Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Define drug effects on food intake - gastro intestinal tract, Define Drug E...

Define Drug Effects on Food Intake - gastro intestinal tract? Affect the gastro intestinal tract: Gastrointestinal irritation and ulceration are serious problems with many drug

Mechanisms that affect the heart rate, Mechanisms that Affect the Heart Rat...

Mechanisms that Affect the Heart Rate Two different mechanisms affect the heart rate. Nerve impulse to the pacemaker region and hormonal influences. A branch of the vagues ner

Describe class agnatha in details, Describe Class Agnatha in details? C...

Describe Class Agnatha in details? Class Agnatha takes its name from the Greek word "gnathos," which means jaw, and "a," which is the prefix for "without." These jawless fishes

Define methods of food preservation, Define methods of Food Preservation? ...

Define methods of Food Preservation? Food preservation is one of the oldest technologies used by human beings. The perishable food materials like fruits, vegetables, milk, meat

What are the types of plant geotropisms, What are the types of plant geotro...

What are the types of plant geotropisms? Why do the stem and the root present opposite geotropisms? The parts of geotropisms are the positive geotropism, that in which the plan

What is the essential morphology of a protozoan cell, Q. What is the essent...

Q. What is the essential morphology of a protozoan cell? Protozoans are eukaryotic cells so they have structures and organelles common to this kind of cell endoplasmic reticula

Centrolecithal egg, which type of cleavage takes place in centrolecithal eg...

which type of cleavage takes place in centrolecithal egg

Explain about the browning reactions, Explain about the Browning Reactions?...

Explain about the Browning Reactions? The Browning Reactions are complex reactions which occur when foods are processed. In some the brown flavour is highly desirable and is in

Neurons, hpw many neurons do we have?

hpw many neurons do we have?

Explain itraconazole, Explain Itraconazole It has a broader spectrum of...

Explain Itraconazole It has a broader spectrum of activity than fluconazole. It is active against a wide variety of fungi including Cryptococcus neoformans, Aspergillus spp., B

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd