Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

How can we examine the chromosomes, Is it more indicated for a geneticist d...

Is it more indicated for a geneticist desiring to map the X chromosome of the mother of a given family (the researcher does not have access to her DNA, only access to the genetic m

Name two forms of respiration gives more energ, Which of the two forms of ...

Which of the two forms of respiration (aerobic and anaerobic) gives more energy from a given quantity of food? Aerobic respiration gives more energy than anaerobic respiration

Zoology, How does classifying animals based on similarities and traits help...

How does classifying animals based on similarities and traits help future scientists

Define keratomalacia - micronutrient deficiencies, Define Keratomalacia - M...

Define Keratomalacia - Micronutrient Deficiencies? This is a condition of rapid destruction and liquefaction of full thickness of cornea, leading lo prolapse of iris, resulting

202, sizes in some biological systems glucose

sizes in some biological systems glucose

Explain valacyclovir, Valacyclovir (Valtrex) - Valacyclovir is an L-val...

Valacyclovir (Valtrex) - Valacyclovir is an L-valyl ester of acyclovir that is metabolized to acyclovir after oral administration, resultingin higher serum concentrations than

Glycogenesis, Glycogenesis :   This  is an anabolic process  in which  gluc...

Glycogenesis :   This  is an anabolic process  in which  glucose is polymerized  into glycogen by the   sequence of  reactions.  Since glycogenesis occur  in all  body  cells .but

Spina bifida occulta, Spina Bifida Occulta There is no protrusion of ...

Spina Bifida Occulta There is no protrusion of the meninges but the vertebrae are bifid. There are three components of the spina bifida occulta. a) Vertebral- there is

Determine the factors affecting fertilizer requirements, Factors Affecting ...

Factors Affecting Fertilizer Requirements   The rapid increase in the use of fertilizers is based on the fact that large profits are obtained from the money invested in them. The

Explain the kidney function in human biology, Explain the Kidney Function i...

Explain the Kidney Function in human biology? Blood first enters the capillaries in Bowman's capsule where it is filtered. The pores in the capillary walls allow water and smal

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd