Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Explain surface area of lipid oxidation, Surface area The rate of oxida...

Surface area The rate of oxidation increases in direct proportion to the surface area of the lipid exposed to air. Furthermore, as surface - volume ratio is increased; a given

Determine the production of red blood cells, What is the substance that sti...

What is the substance that stimulates the production of red blood cells? Which is the organ that secretes it? Under what conditions does this secretion increase? The substance

Define water as a source of dietary minerals, Define Water as a source of d...

Define Water as a source of dietary minerals? Although water is composed of only oxygen and hydrogen, the water we drink or use in food preparation can contain significant amou

Explain micronutrient, Which one of the following is not a micronutrient? ...

Which one of the following is not a micronutrient? 1. Molybdenum 2. Magnesium 3. Zinc 4. Boron. Magnesium

Portal hypertension, Portal Hypertension: If you review the portal cir...

Portal Hypertension: If you review the portal circulation you may recall that normal blood flow to and from the liver depends on proper functioning of  the portal vein, the he

Fat soluble vitamin needs of school children and adolescents, Determine Fat...

Determine Fat Soluble Vitamin Needs of school children and adolescents? ICMR (1990) does not give recommendations for vitamin D, E and K. Vitamin D is very important for skelet

Difference between rough and smooth endoplasmic reticulum, Q. What is the d...

Q. What is the difference between rough and smooth endoplasmic reticulum? The endoplasmic reticulum is a delicate membranous structure contiguous to the nuclear membrane as wel

What do you understand by myoglobin, Q. What is myoglobin? What is the func...

Q. What is myoglobin? What is the function of this molecule in the muscle tissue? Myoglobin is a present in muscle pigment and fibers similar to hemoglobin. Myoglobin has a gre

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd