Define effect of feeding method on drug availability, Biology

Assignment Help:

Define Effect of feeding method on drug availability?

The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.

Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.


Related Discussions:- Define effect of feeding method on drug availability

Explain the microscope, Explain the Microscope? Microscope is a powerfu...

Explain the Microscope? Microscope is a powerful and crucial basic tool in the field of microbiology. Microbiology, as we have already studied in our theory Course, is the scie

Guiding and overseeing actions of consciousness, Q. Guiding and overseeing ...

Q. Guiding and overseeing actions of Consciousness? Guiding and overseeing actions: Consciousness connects brain and body states with external occurrences. In order to functio

Define elongation phase - mechanism of protein synthesis, Define Elongation...

Define Elongation phase - mechanism of protein synthesis? Elongation: RNA polymerase moves along the DNA and sequential synthesizes the RNA chain. There is the repeated cycle o

What are the three main limiting factors of photosynthesis, What are the th...

What are the three main limiting factors of photosynthesis? The three major limiting factors of photosynthesis process are light intensity, carbon dioxide concentration and tem

Describe about cardiomyopathy due to persistent tachycardia, Q. Describe ab...

Q. Describe about Cardiomyopathy due to Persistent Tachycardia? In occasional cases, particularly in children recurrent or incessant episodes of supraventricular or ventricular

Explain the stage of the cardiac cycle, Q. What is the stage of the cardiac...

Q. What is the stage of the cardiac cycle during which the ventricles are filled? The filling of the ventricles with blood take place during diastole.

Describe about the term - neuropsychological assessment, Describe about the...

Describe about the term - Neuropsychological assessment Neuropsychological assessment has its roots in neurology, the branch of medicine that focuses on the nervous system and

Illustrate the structure of the central nervous system, Q. What is the stru...

Q. What is the structure of the central nervous system that regulates pulmonary respiration? The reaction is catalyzed by the enzyme carbonic anhydrase present in red blood cel

Bones, which bone forms the non-moving muscle attachment in the hip joint

which bone forms the non-moving muscle attachment in the hip joint

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd