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Define Effect of feeding method on drug availability?
The form in which a drug is administered or enters the body can influence its absorption, metabolism or excretion. This becomes more pronounced among critically ill patients who cannot consume drugs orally and are on enteral food support. If the drug has to be administered though the enteral feeding tube it needs to be either crushed or dissolved in a solvent. Crushing oral preparations to pass down the tube may alter their absorption time/activity.
Some of the drugs cannot be added to the food infusion as it may alter their stability. Several drugs are available only in the form of tablets or capsules, dissolving these in feed, water, alcohol or sorbitol may not always be feasible. Drug such as cimetidine, aluminium hydroxide, metaclorpromide are physically incompatible with enteral foods. Certain drugs like phenytoin form complexes with calcium and protein thereby resulting in markedly reduced absorption of this medication. Such drugs need to given only by stopping enteral feed infusions for 1-2 hours. Patients on total parenteral nutrition generally have a separate tube (catheter) for infusion of drugs. Toxicity/over dosage of drugs is frequently observed in case of certain drugs administered directly into the blood.
levels of biodiversity
Determine the purposes of vital signs The vital signs reflect the functioning of vital organs of the body i.e. heart, brain and lungs. They indicate the basic functions of body
characterstic of phylum arthropoda
Define the Causes of Instrument Fracture Too much apical pressure ( specially in narrow or curved canal) Used in dry canal without irrigation or lubricant Excessi
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CODOMINANCE The alleles which do not show dominance-recessive relationship and are able to express themselves independently when present together are called codominant alleles.
Osmoregulation in Marine Non-Chordate Metazoans Studies on the osmotic pressure of body fluids of marine organisms have displayed that their internal osmotic pressure is more
PLANNING FOR EVALUATION: The need for clearly defined objectives for the evaluation process, analysis of the need for it, systematic measures for accomplishing its purpose an
What was the experiment of Stanley Miller (1953) on the origin of life? In 1953 the Stanley Miller arranged an experimental apparatus that simulated the atmospheric conditions
Formation of cocoon in earthworm: In earthworm segments from 14 to 17 are swollen. Skin on these segments is thick and glandular. This is called clitellum. When ovaries ma
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