In the long term reversible causes of heart failure like valvular lesions, myocardial ischemia, uncontrolled hypertension, arrhythmias, alcohol, negative inotropic agents, intracardiac shunts, and high-output states should be identified and corrected.

Some metabolic and infiltrative cardiomyopathies may be partially reversible, or their progression may be slowed; these include hemochromatosis, sarcoidosis, and amyloidosis.

Reversible causes of diastolic dysfunction include pericardial disease and left ventricular hypertrophy due to hypertension.