The major concentration of noradrenergic (and adrenergic) cell bodies is found in locus ceruleus a nucleus in the reticular formation. The axons of these neurons project through the medial forebrain to the cerebral cortex, the limbic system the thalamus and the hypothalamus.

Receptors

The two broad groups of adrenergic and noradrenergic receptors are á-adrenergic receptors and â-adrenergic receptors. The á-adrenergic receptors are further subdivided into two types á1, á 2 and â-adrenergic receptors are subdivided into â1 â2 and â3 . The â1 subtype predominates in the cerebral cortex and â2 in the cerebellum.