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Q. Why can it be said that each glucose molecule runs the Krebs cycle twice?
Each glucose molecule "cycles" the Krebs cycle twice because after glycolysis each used glucose has generated two pyruvic acid molecules and each pyruvic acid is converted in a 1:1 proportion into acetyl CoA Each acetyl CoA then cycles the Krebs cycle once.
The scientist who described cells as “many little boxes” was
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