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Animal disease model
The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.
Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.
The chemicals responsible for imparting the sweetness, classic salt taste and bitter and sour taste are summarized herewith. A. Sweet Taste Sweetness is one of the most importa
Reproductive Cycle The whole reproductive cycle consists of an ovarian cycle and a uterine cycle. Figure illustrates one complete reproductive cycle. You can observe in the fi
This is a rare manifestation seen in less than 5 per cent of ARF patients. It is erythematous, macular, evanescent, non-pruritic rash with pale centre and serpiginous or rounded bo
The use of the gums in various foods may affect the following functional properties: 1. Water-binding capacity 2. Rheological properties 3. Capacity to form film or gel
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Homozygous and Weterozygous In an individual two identical alleles may exist [or a given character and, hence, the individual is referred to as Homozygous (e.g. AA and aa). If
What are fossil fuels? Fossil fuels, like oil, gas and coal, form when organic material is preserved from the complete action of decomposers, generally buried deep and under pr
Q. Describe False Negaive Tests? When patients are found to have significant coronary narrowing and fail to have exercise induced ST depression, they have been labeled false ne
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