Allele-specific ligation, Biology

Assignment Help:

Allele-specific ligation is the technique permitting discrimination of two allele at locus by giving two short synthetic oligonucleotides which would bind ajjacent to teach other on amplified DNA fragment, and would be ligated in the presence of DNA ligase; if one of alleles comprising mutation overlapped by 3'-end of one oligonucleotide, its ligation to oligonucleotide bound 3' to it would be prevented; to deduce the identity of the unknown allele, differentially labelled oligonucleotide pairs might be designed for each allele and their ligation efficiency compared in the presence of unknown allele.


Related Discussions:- Allele-specific ligation

Mechanism of carcinogenesis, Mechanism of Carcinogenesis In the preced...

Mechanism of Carcinogenesis In the preceding sub-section you learnt that carcinogenesis is a multistep process. Even though cancer may be caused by many agents chemical, p

Define partition chromatography - basic separation technique, Define Partit...

Define Partition chromatography - basic separation technique? It is a technique in which separation is achieved as a consequence of the relative solubility of a substance in th

Class of subphylum uniramia - pauropoda, Class of Subphylum Uniramia - Paur...

Class of Subphylum Uniramia - Pauropoda A small group of uniramians, there are 500 species of Pauropoda explained so far. The minute organisms computing about 1.5 mm in length

All or None Response, All or None Response A very weak stimulus does n...

All or None Response A very weak stimulus does not result in an action potential. The stimulus must have a certain strength to evoke an excitation. This is the threshold value

Bacterial food infections, Food infection occurs when a pathogen enters the...

Food infection occurs when a pathogen enters the gastrointestinal tract and multiplies. Microorganisms can penetrate into the intestinal mucosa and grow there, or they can pass thr

Explain the crestal bone levels, Explain the Crestal Bone Levels Cresta...

Explain the Crestal Bone Levels Crestal Bone Levels: Bone levels should be assessed on the mesial and distal surfaces of implants.  Any changes between visits should be documen

Explain measurement of cell mass - microbial estimation, Explain Measuremen...

Explain Measurement of Cell Mass - Microbial Estimation? You may recall reading earlier that filamentous bacteria and moulds cannot be counted satisfactorily by employing plate

Contig, Contig:  Number of uses, all nouns. The term comes from the shorten...

Contig:  Number of uses, all nouns. The term comes from the shortening of the word 'contiguous'. A 'contig' might refer to the map showing placement of a set of clones which comple

Explain subphylum vertebrata, Subphylum  Vertebrata : (41,700 species, th...

Subphylum  Vertebrata : (41,700 species, the vertebrates) Vertebral column of bone or cartilage, head is well developed, heart is ventrally situated dorsal aorta, two pairs of

Define the spray drying method, Define the Spray Drying Method? Spray d...

Define the Spray Drying Method? Spray drying is a unique drying process since it involves both particle formation and drying. It is most suitable for drying of liquid foods suc

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd