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Small- and medium-chain acyl CoA molecules (up to 10 carbon atoms) are readily capable to cross the inner mitochondrial membrane by diffusion. Furthermore, longer chain acyl CoAs do not readily cross the inner mitochondrial membrane, and requires a specific transport mechanism. To achieve this, the longer chain acyls CoAs are conjugated to the polar carnitine molecule that is found in both animals and plants. This reaction, catalyzed by an enzyme on the outer face of the inner mitochondrial membrane (carnitine acyltransferase I), erased the CoA set and substitutes it with a carnitine molecule shown in the figure. The acylcarnitine is then transported with the inner mitochondrial membrane by a carnitine or acylcarnitine translocase.
Figure: Activation of a fatty acid.
Transmissible gastroenteritis of swine The disease, first reported from the USA in 1964, is caused by antigenic group 1 mamalian coronavirus, a member of genus Coronavirus of
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