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Question - 1- As discussed, new mutations are part of DNA replication. The overall error rate of DNA biopolymerase in the replisome is 10-8 errors per base pair in humans. Repair enzymes fix 99% of these lesions. The human haploid genome is 3.2 * 109 bp.
a. What is the average number of mutations introduced when the genome is replicated?
- In males, there are approximately 400 cell divisions between zygote and production of a sperm cell.
b. How many mutations are to be expected in every sperm cell?
- In a female, there are about 30 cell divisions between zygote and production of egg cell:
c. How many mutations are expected in an egg cell?
d. How many mutations are expected in a new zygote?
e. Give a brief explanation what these mutations can result in from the evolutionary view, assuming they are a mutation that causes an amino acid change in a protein.
Show all the steps in the mechanism for the following reaction, When benzene is mixed with deuterated sulfuric acid, deuterium is slowly incorporated onto the ring. Show the mechanism for this reaction and explain how this relates the sulfonation of ..
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