Sample size for clinical trial

Reference no: EM1394251

The Physician's Health Study was a randomized clinical trial, one of whose goals was to effect of cigarette smoking on the development of myocardial infarction preventing myocardial infarction (MI).

Suppose that the incidence of MI is 0.005 per year among subjects who are actually take placebo and that aspirin prevents 20% of MIs (i.e. relative risk=p1/p2=0.8). We also assume that the duration of the study is 5 years, and during study, there is neither drop out nor drop in.

How many subjects need to be enrolled in each group to achieve 80% power using two-sided test with significance level=0.05?

Reference no: EM1394251

Questions Cloud

Illustrate what is corporate tradition : Donna Hamilton is excited to open her own restaurant, the Westminster Inn. Although Donna has worked as a chef also even managed a number of restaurants during her career.

Prepare four basic financial statements : Review the financials and the notes to the statements. Briefly report to the class what you found interesting.

Gene regulation in eukaryotes : For gene regulation in eukaryotes - under what conditions will -interferon be transcribed at the highest rate? Why? (if possible, would like something that would have to do with GAL yeast and less virus-linked.

Create a hypothetical code of ethics : Discuss explain how the concept of sustainability fits into the theory of corporate social responsibility.

Sample size for clinical trial : Suppose that the incidence of MI is 0.005 per year among subjects who are actually take placebo and that aspirin prevents 20% of MIs

Standard screening test for downs syndrome : The standard screening test for Down's syndrome is based on a combination of maternal age and the level of serum alpha fetoprotein. Using the test 80% of Down's syndrome cases can be identified while 5% of normals are detected as positives.

What general recommendations improving the ethical standings : Lecture on managerial ethics, criteria for ethical decision making also manager ethical choice.

Margin of error-sample size : Suppose that it is a presidential election year and Ohio is one of the 'swing' states. Your polling company wants to conduct a presidential preference poll of the citizens of Ohio to predict which candidate will win the election.

Explain computation of bond liability : Messier Inc. manufactures cycling equipment. Recently the vice president of operations of the company has requested construction of a new plant to meet the increasing demand for the company's bikes. Explain Computation of Bond Liability

User Account

All Pages