Improvement in cardiac function

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Reference no: EM133920283

Question

Bloodwork reveals a normal ESR (a non-specific measure of inflammation), normal hemoglobin, hematocrit, white blood cell count/distribution, albumin and blood glucose levels. Chest X ray show some shadowing of lung tissues more prominently in the base, confirming the presence of edema. The ventricles of the heart are enlarged. No other abnormality noted. A 24 hour urine collection revealed no abnormalities.

Given the above information, you diagnose him with congestive heart failure. You consider various medications for his treatment, which aim to improve his cardiac function by slowing the rate and increasing contractility. Digoxin is one such drug (though it does appear to have a 20% higher all-cause mortality rate in atrial fibrillation patients, so it is not given without careful consideration).

Question

How does digoxin work in terms of altering movement of Na+, K+ and Ca++ and how does that relate to the improvement in cardiac function (increased contractility and slower heart rate)?

Reference no: EM133920283

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