Reference no: EM13511423

As a specialist in biochemistry, you have been asked to be part of a team that will assist a country without regulatory legislation. You will help the other workers in understanding BSE at a chemical level. Because these workers are unfamiliar with the basic biochemistry concepts necessary to understand how BSE occurs, you will need to include an overview of proteins.

Requirements:

Design either a multimedia presentation (e.g., PowerPoint, Keynote, Google Presentation) or a report (e.g., Microsoft Word, Google Document) for health workers on the biochemistry of BSE by doing the following:

Note: You are not limited to a specific length, but suggested lengths are 10-15 slides for a presentation and 3-5 pages for a report.

Note: Please save submission documents as *.ppt, *.pptx (PowerPoint), *.key (Keynote), *.doc, *.docx (Word) or *.pdf (Portable Document Format) files. If you are using Google Presentations or Documents you must save the file in *.pdf format and upload the *.pdf file.

A. Create an original model of an essential amino acid that shows all atoms and bonds in both the backbone and the side chain.

1. Describe two characteristics (e.g., reactivity, hydrophobicity, how it affects the structure or functions of a protein) for the amino acid model you created in part A.

B. Create an original diagram, or series of simple diagrams, of the different levels of protein structure.

1.  Label the primary, secondary, tertiary, and quaternary structures in your diagram(s).

C. Create an original diagram, or series of simple diagrams, that demonstrates how a peptide bond is made through dehydration, using a complete chemical equation that includes the following components:

• chemical structures of all reactants
• an arrow indicating the direction of the reaction
• the chemical structures of all products

D. Create an original diagram, or series of simple diagrams, that demonstrates how a peptide bond is broken through hydrolysis, using a complete chemical equation that includes the following components:

• the chemical structures of all reactants
• an arrow indicating the direction of the reaction
• the chemical structures of all products

E. Explain the four forces (i.e., bonds or interactions) that stabilize a protein's structure at the tertiary level of protein structure.

F.   Explain how bovine spongiform encephalopathy (BSE) occurs at a molecular level by doing the following:

1.  Explain the role of protein misfolding and aggregation in BSE, including the following points:

• the name of the protein that is misfolding
• why the protein is misfolding
• why there is aggregation
• what structures the aggregated proteins form
• how this process leads to the symptoms of BSE

2.  Explain the role of prions in BSE, including the following points:

• what a prion is
• the name of the prion in BSE
• how prions lead to the disease

3.  Explain the role of the chaperone protein in BSE, including the following points:

• how chaperones normally act in the cell
• the name of the specific protein that acts as a chaperone in BSE
• how the protein that acts as a chaperone is different from typical chaperone proteins

4.  Recommend ways that a country that does not have regulations in place can decrease the risk of BSE infecting the food source, based on your understanding of BSE and how it spreads (e.g., feeding practices, animal disposal).

G. When you use sources, include all in-text citations and references in APA format.