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For example a functional group that exhibits a basic pka of

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The following is a list of drugs. For this assignment, use any resources available to you to find the structures of these drugs and then identify the functional group or groups in each molecule that is significantly ionized (>0.1%) at physiological pH (7.4) and give an approximate pKa value for each functional group (+/- 1 pKa unit).

Atropine

  • Ephedrine
  • Phenobarbital
  • Cocaine
  • Morphine
  • Warfarin

For example, a functional group that exhibits a basic pKa of 4.4 is significantly ionized at pH 7.4 while a functional group that exhibits an acidic pKa of 10.4 is significantly ionized at pH 7.4 but those are the limiting pKa values for meeting the criteria.

Reference no: EM13585158

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