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Question: For many years the benefits of routine use of female hormone supplements (estrogen + progesterone) by postmenopausal women have been debated. An American study, the "Women's Health Initiative", compared 8506 women randomized to taking daily hormone supplements to 8102 women randomized to placebo (JAMA 2002;288:321-33). The results were against (positive) expectations.
Results
Hormone supplements (n = 8506)
placebo
(n = 8102)
Average follow-up in months (standard deviation)
62.2 (16.1)
61.2 (15.0)
Cardiovascular disease
695
546
Cancer
502
458
Fractures
650
788
Died
231
218
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