Explain the detoxification of acetaminophen

Reference no: EM1317313

Explain the detoxification of Acetaminophen, alcohol, and sodium nitrite with biotransformation of xenobiotics. Describe the Synthesis of fatty acid, Triglyceride, Vitamin E, and Vitamin C.

Scenario: An individual eats meats with much sodium nitrite, also drinks ethanol (alcohol), taking vitamins E and C, while also taking four tablets of 500 mg Tylenol. Develop the following components of the question with brief organic chemistry explanations of what is happening and integrate the interactions of these ingested items.

1. Acetaminophen Phase I- Detoxification [show this to be occurring at the smooth ER] (cytochrome P 450) Phase II- Detoxification [show this occurring in the cytoplasm] (Glutathione SH) [Be sure to include GSH and explanation of why the conjugate basically stays in the blood] Pain reduction by blocking conversion of arachidonic acid.

2. Alcohol Detoxification
Alcohol Dehyrdogenase
NADH
GSH

3. Sodium nitrite
Formation of carbocations
Vitamin C

4. Potential Lipid Radicals formed from superoxide [may form from converting 02 into water] or hydroxyl radicals that could be affected by the sodium nitrite's utilization of vitamin C. Show how a fatty acid is made and then show the assembly of a triglyceride Synthesis of fatty acid
Triglyceride
Vitamin E
Vitamin C

Integration: How can liver damage result due to the intake of ethanol and Tylenol, but also how could liver damage occur even if ethanol was not ingested?

Reference no: EM1317313

Questions Cloud

Find the amount of energy present : Calculate the amount of energy present in the following photons and find the region of electromagnetic spectrum for each.

Significance level of guideline : At the .05 significance level, can we conclude that the guideline is still reasonable?

Find change in the fraction of visibility for a person : Find the change in the fraction of visibility for a person from planet Krypton with x-ray vision in addition to visible spectrum.

Explain capital gain from bonds : Explain Capital Gain from Bonds and Meade Corporation bonds mature in 6 years and have a yield to maturity of 8.5 percent

Explain the detoxification of acetaminophen : Explain the detoxification of Acetaminophen, alcohol, and sodium nitrite with biotransformation of xenobiotics. Describe the Synthesis of fatty acid, Triglyceride, Vitamin E, and Vitamin C.

Explain free rider problem : How does the free rider problem explain why telephone companies are usually successful in getting permission to raise their rates?

Determine the percent by mass of calcium carbonate : Determine the percent by mass of calcium carbonate in the sample

Evaluate the molecular formula of the compound : Application of Boyle's Law - Determine the molecular formula of the compound

Evaluate the volume of a gas using avogadro''s law : Application of Avogadro's law - To evaluate the volume of a gas using Avogadro's Law.

User Account

All Pages