Reference no: EM133083006

Techniques in Drug Discovery

Question 1. Explain the physical basis of drug-receptor interactions and how these lead to biological activity;

Question 2. Explain the concepts of agonism and antagonism, and how these can be classified and quantified;

Question 3. Choose appropriate experimental assays for screening, quantification and optimisation of a specified biological activity;

Question 4. Explain the parameters that are used to describe the physico-chemical properties of compounds;

Question 5. Use structure activity relationships to make predictions about the activity of compounds;

Question 6. Use the concepts of SAR, isosteres and pharmacophores to aid design of novel compounds;

Question 7. Apply rules to predict lead-like and drug-like compounds;

Question 8. Describe the principles of computational techniques that are used in drug discovery and optimisation;

Question 9. Critically discuss the merits and disadvantages of different strategies and techniques in drug discovery.