Develop a detailed analysis plan to investigate

Assignment Help Applied Statistics

Reference no: EM133874106

Introduction to Biostatistics

Problem Set Instructions
Problem set is a culmination of the information from Weeks

Data: You will be using the HINTS 4 (Cycle 2) data to answer the assessment questions. This data set and accompanying codebook were updated in 2017. A random sample of size of 1500 was taken to simplify data handling. The data are available Hete,_ .Rdata format. You will need to download and save the data file onto your computer and then LOAD it into R Commander.

Note that data have not been recorded nor changed in any way but R automatically made some variables factors if there was only a small number of values. The variable names match those Si the codebook. You may find it easier to remove variables that you don't need to make
data handling and using the analysis menus more manageable (Data => Manage variables in active data set => Delete variables from data set...)

Finally, you may see a reference to analysis using sample weights. While this is common in complex surveys, statistical analyses should not be weighted for (:)1.

The answers to Q1 must include:
what observations do you use (inclusion/exclusion)
and selection of appropriate statistical measures and why,
an appropriate presentation of the data in graphs and tables,
statements about assumptions, testing of the assumptions, and
appropriate conclusions based on statistical tests, with justification In text.
Report the p-value to 2 or 3 decimal places (p=0.02, p<0.001, p=0.008, for example) and other values to 1 or 2 decimal places or whole numbers if appropriate.

Background of the Data:
The Health Information National Trends Survey (HINTS) is a national survey uniquely dedicated to learning how people find, use, and understand health information

Question 1:
Consider body mass index (BMI) as a continuous variable. Is BMI related to annual income (IncomeRanges_IMP) when income is considered to be 4 categories (10 to $34,999", "$35,000 to $99,999", "$100,000 to $199,999" and "$200,000 and above")? Comment on the similarity or otherwise of the relationship between men and women [Gender (GenderC)].
Note: The variable names are in brackets, and their details may be found in the codebook.
You DO NOT submit your Problem Set answers this week. Q1 is not due this week (week 7) but we highly recommed completing this week as you will need to submit it in week 13 once you have completed Q1 to Q6. You can check the due date on the Course Profile (Blackboard > Course Profile > Assessment).

Question 2 Background.
You might need to log in to the UQ network to access the article's full text. This question relates to the following journal article:
Article 1: Effect of SacubitrilNalsartan vs Valsartan on Left Atrial Volume in Patients With Pre-Heart Failure With Preserved Ejection Fraction The PARABLE Randomized Clinical Trial, AMA. 2023 (doi: 10.1001/jamacardio.2023.0065)
Question:
Develop a detailed analysis plan to investigate the relationships between the treatment and the following variables listed in Table 1 of Article 1: Age, BMI, Total cholesterol, Diabetes, and Coronary artery disease. Additionally, include a brief analysis plan to explore the relationship between the primary outcome variable and baseline heart rate, stratified by treatment.
Do NOT do the analysis!
You DO NOT submit your Problem Set answers this week. Q2 is not due this week (week 9), but we highly recommend completing this week as you will need to submit it in week 13 once you have completed Q1 to Q6. You can check the due date on the Course Profile (Blackboard > Course Profile > Assessment).

Question 3: Background:
You might need to log in to the UQ network to access the article's full text. This question relates to the following journal articles:
Article 1: Effect of SacubitrilNalsartan vs Valsartan on Left Atrial Volume in Patients With Pre-Heart Failure With Preserved Ejection Fraction The PARABLE Randomized Clinical Trial, JAMA. 2023 (doi: 10.1001/jamacardio 2023.0065)

Question:
Article 1 includes a sample size calculation for the primary outcome variable. Your task is to calculate the required sample size for the study, assuming that the difference between the treatment groups for the average primary outcome in the population is 2.79 and the within-treatment group variance is 47.2. You should use the type I and type II error rates to be 5% and 20%, respectively and adjust for a 10% dropout rate. After performing the sample size calculation, discuss the advantages and disadvantages of the study if it had been designed with 10% higher power than the current. Get online assignment help from Ph.D. experts!

Question 4 Background;
You might need to log in to the UQ network to access the article's full text. This question relates to the following journal articles:
Article 2: Physical activity and diabetes mortality in people with type 2 diabetes: a prospective cohort study of 0.5 million US people, Diabetes & Metabolism. 2023 (doi: 10.10164.diabet.2022.101410)

Question:
Article 2 presents information on the study design, sampling techniques, and participants. Write a concise and clear summary of these aspects of the study in your own words (200 words). Additionally, discuss the advantages and disadvantages of using simple random sampling to recruit participants from the target population had it been used in this study (150 words). Finally, justify whether the study's analysis accounted for the sampling techniques used and provide a rationale for your answer.

Question 5:

Background:

You might need to log in to the UQ network to access the article's full text. This question relates to the following journal articles:

Article 2: Physical activity and diabetes mortality in people with type 2 diabetes: a prospective cohort study of 0.5 million US people, Diabetes & Metabolism. 2023 (doh 10.1016/j.diabst.2027.101410)
Question:
Article 2 employs two sets of survey questions to measure physical activity. Evaluate the reliability and validity of moderate physical activity (MPA) survey questions. (200 words)

Question 6:

Background:
You might need to log in to the UQ network to access the article's full text. This question relates to the following journal articles:
Article 1: Effect of SacubitrilNalsartan vs Valsartan on Left Atrial Volume in Patients With Pre-Heart Failure With Preserved Ejection Fraction The PARABLE Randomized Clinical Trial, JAMA. 2023 (dol: 10.100jiljamacardio.2023.0065)
Article 2: Physical activity and diabetes mortality in people with type 2 diabetes: a prospective cohort study of 0.5 million US people, Diabetes & Metabolism. 2023 (doh. 10.1016rj.diabet.2022.101410)

Question: Summarise data quality assurance procedures that might have been employed in Article 1 compared to Article 2. (150 words)

Reference no: EM133874106

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