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Detect a mean difference of 5 units in the symptom

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Reference no: EM13510461

In a 5-year follow-up of bilateral stimulation of the subthalamic nucleus among 49 patients with advanced Parkinson's disease, investigators assessed changes in symptoms as measured by the Unified Parkinson's Disease Rating Scale (range = 0 to 108, with higher values denoting more
symptoms). Assume this measure follows a normal distribution. The mean score at baseline was 55.7. The standard deviation of change from baseline to 5 years was 15.3.

8.175 How much power does this study have to detect a mean difference of 5 units in the symptom scale if a two sided test is used with α = .05?

8.176 What minimum sample size would be needed to detect a mean change of 5 units with 80% power if a two sided test is used with α = .05?

8.177 The above study had no control group. Assuming that the same standard deviation of change would occur among controls and the mean change among controls = 0, how many participants would be necessary to detect a mean difference of 5 units of change between those receiving stimulation and a control group of equal size with 80% power if a two-sided test is used with α = .05?

Please follow the book "Fundamentals of biostatistics"

Reference no: EM13510461

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