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1. Describe the mechanisms of action, biochemical targets and effects of these lipid-lowering drugs; statins, niacin, fibrates, colestipol, torcetrapib, avasimibe, implitapide, praluent and ezetimibe?
2. What are SREBP and SCAP? What roles do they play in the cholesterol homeostasis?
3. A nonfunctional MTP gene/protein causes ABL.What are the possible effects on lipid levels and cardiovascular pathology if this protein is overexpressed?
4. Based on your understanding of the role of ABCA1 in the formation of HDL particles,how would you design a therapeutic modality to overcome a weakened interaction between ABCA1 and apoA-I that results from a mutation in ABCA1 gene?
How would you modulate the reverse cholesterol transport?
What mass of NaHCO3 (M = 84.0) is required to completely neutralize 25 mL of 0.125 M H2SO4? answer is 0.525 g please expline how
A mixture of 40 Ml of methyl butyrate (MW-102.1 g/mol,d-0.89 g/mL) and 10 mL butyric acid (MW=88.1 g/mol, d=0.96 g/ML) is distilled.
If a coordination compound absorbs in the visible region of the electromagnetic spectrum. Determined that a 0.0378M solution of this compound in a 3.41 cm cuvette has an absorbance maximum of 0.871 at 575 nm. Compute the molar absorbtivity of the ..
The volume of a gas sample is 200L at 740 torr. what is its volume at 760 torr? Assume that the Temperature remains constant
Many odors from solvents, perfumes, and paint strippers are derived from aldehydes or ketones
50.0mL of 0.15 M cobalt(II) nitrate is diluted to 250 mL with water. What is the final concentration of cobalt(II) nitrate
Suppose you were to heat the copper in argon gas instead of atmospheric gasses. Given that argon is relatively inert, which of the following would you expect if you were to heat pure copper in the presence of argon gas?
A solution is prepared by dissolving 76.3 g NaI in 545 g of water. Determine the mole fraction of NaI if the final volume of the solution is 576 mL.
The Iron(3) ion have five unpaired electrons. In octahedral coordination complexes, it may have either one or five unpaired electrons. Using valence bond theory: 1. Draw and name the hybrid orbital schemes for these two situations
It decomposes into its elements. Write the balanced equation for this reaction. If 71.8 g of Hgo is decomposed, calculate the volume of oxygen at STP
Problem- The explosive nitroglycerin (C3H5N3O9) decomposes rapidly upon ignition or sudden impact according to the following balanced equation: Calculate the standard enthalpy of formation (?H?f) for nitroglycerin
Consider the reaction given below. H2(g) + F2(g) 2 HF(g) (a) Using thermodynamic data from the course website, calculate G° at 298 K. kJ (b) Calculate G at 298 K if the reaction mixture consists of 7.3 atm of H2, 5.3 atm of F2, and 0.22 atm of HF.
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