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Cocaine overdose and addiction are major public health problems. One novel treatment involves the administration of high activity mutants of human butyrylcholinesterase (BChE) (i.e. this would be a protein-based ‘drug') that would hydrolyze and detoxify cocaine.
Explain how His438 and Glu325 act together to generate a better nucleophile at Ser198.
The Ser198Ala, His438Ala, Glu325Ala triple mutant still catalyzes the ester hydrolysis of cocaine by a ~1000-fold over the uncatalyzed reaction.
Explain how the triple mutant enzyme can still catalyze the reaction when the catalytic triad has been ‘knocked out.'
One mutation that increases the catalytic activity of BChe is the Ala199 to Ser mutation. The hydroxyl group of Ser199 makes a hydrogen bond interaction with the carbonyl oxygen in the cocaine ester. Explain how an extra hydrogen bond to this carbonyl oxygen may increase the enzyme's catalytic rate.
Compute the vapor pressure at the temperature of 25 degree Celsius of H 2 O above a solution formed by mixing 100.
Calculate the mass percent of a solution that is prepared by adding 61.4 g of rm NaOH to 413 g of {rm H_2O}.
Magnesium Hydroxide is a slightly soluble substance. If the pH of a saturated solution of Mg(OH)2 is 10.49 at 25 degrees celcius, calculate Ksp for Mg(OH)2.
A 0.1mL Pure Acid phosphatase (0.5mg/ml) hydrolyzes 0.2mmol of pnPP wall in 5 min. what is the specific activity?
Calculate the sample of concentration. Is this an appropriate concentration for 1H NMR, 13C NMR or both?
The active catalyst in this experiment was generated from the redox reaction of chloroplatinic acid with sodium borohydride. What is the active catalyst?
When adding ethylene glycol to your cooling system, it is usually mixed 50:50 by volume. This will prepare a 52.7 mass % solution. Convert this concentration to molality and predict the freezing point depression
A 5.0 ml sample of vinegar was titrated with 7.2 ml of 0.55 M NaOH. if the density of vinegar solution is 1.00g/ml, what is the mass percent of acetic acid present.
Caffeine, C8H10N4O2, is a stimulant found in tea and coffee. A sample of the substance was dissolved in 41.5 g of chloroform, CHCl3, to give a 0.0940 m solution.
If each mole of gas occupies 55 L under the conditions of the explosion, how many liters of gas are produced? c) how many grams of N2 is produced in the detonation?
At -13.0 °C (a common temperature for household freezers), what is the maximum mass of sucrose (C12H22O11) you can add to 3.00 kg of pure water and still have the solution freeze?
This given reaction: 2 O3(g) -→ 3 O2(g) has an empirically determined rate law (with a single unimolecular event). Determine what is the observed rate If k =4.0 × 105s-1, [O2] = 0.2M and [O3] = 0.5 M?
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