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Question: A diffusion cell is constructed that consists of a thin membrane (thickness 200 micro meters and area 1 cm^2) separating two solutions of identical volume (V= 10 cm^3). The donor solution contains a drug molecule of interest. The drug has a partition coefficient of 15 in the membrane. State all your assumptions and boundary conditions in the calculation.1) If the donor solution concentration remains unchanged at 10 mg/ml. The receptor solution is maintained at a much lower concentration. The amount of drug that passes through the membrane is 6.5 mg/hr. Calculate the drug diffusion coefficient and permeability in the membrane.(2) If the initial drug concentrations are 10 mg/ml in the donor solution and 0 mg/ml in the receptor solution. The change in the drug concentration in the receptor solution is measured as a function of time, as shown in the table below. Also shown is the drug concentration change when the membrane is treated with a thin layer of coating. Determine the permeability of the membrane with and without coating to the drug.Time (min) Without coating (mg/ml) With coating (mg/ml)0 0 060 0.45 0.1300 1.35 0.5900 2.5 1.3
The main of eukaryotic cells are on the order of 10-100 micrometers in diameter. Bacterial cells are smaller, typically in 1-10 micrometers.
In the aerials competition in skiing, the competitors speed down a ramp that slopes sharply upward at the end. The sharp upward slope launches them into the air, where they perform acrobatic maneuvers.
Assume that there are 63 different naturally occurring amino acids. If all 64 possible combinations of bases for a codon resulted in coding for 63 different amino acids and one stop codon, which of the next mutations would NOT be possible.
A generalized transducing phage is used to transduce an a-b- c- d- e- recipient strain of E. coli with an a+ b+ c+ d+ e+ donor.
The "Primordial soup" includes the mixture of elements and gases which are thought to have started life on the Earth. Explain one thing in biosphere you would like to modify. Why do you feel this way? What do you think can be accomplished to implem..
Is a catalase test perfromed on colonies from a BAP? State reasons to support your answer.
Early in development, most human cells turn off expression of essential component of telomerase, enzyme responsible for addition of telomere repeat sequences (5' TTAGGG 3') to the ends of chromosomes.
Is habitat temperature reflected in the genomes? What is presumably connected to thermostability.
Explain how adult stem cells can sense and respond to the nutritional status of an animal. Explain what kind of cues an adult stem cell can respond to, and where these cues are coming from.
Summarize the two various camps of thought on the life cycle of Pfiesteria. Which set of the arguments do you determine.
The global community is plagued by increasing incidence of lung cancer, colorectal cancer, breast and pancreatic cancers, prostate cancer, leukemia, non-Hodgkin lymphoma, liver, ovarian and esophageal cancers.
We have 2-eyes and 2-ears, yet we can see and hear very-well with only one. So, why do we have two? We have studied how having two eyes.
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