Reference no: EM134014520

Question

In this section you are going to investigate two forms of Hexokinase, the first enzyme in glycolysis. You have already looked at structure 4QS7, which is the structure of Hexokinase with glucose bound. Now you will also look at structure 4QS8, which is hexokinase without glucose.

Open structure 4QS7: Visualize the amino acids T194, N229, N256, and E315.

Using the measurement tool determine the closest distances between the functional groups at the end of following amino acid side chains (units are Angstroms):

1. Between T194 and E315:

2. Between N229 and N256:

Open structure 4QS8: Visualize the amino acids T194, N229, N256, and E315.

Using the measurement tool determine the closest distances between the functional groups at the end of following amino acid side chains (units are Angstroms):

3. Between T194 and E315:

4. Between N229 and N256:

5. Save a picture of structure 4QS8 and upload.

6. Briefly propose a molecular mechanism for the differences between the structures you uploaded in #5 (in other words, how did the structures become different?)