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Q1) Certain fraction of antibiotics injected into bloodstream are "bound" to serum proteins. This is phenomenon of considerable pharmacological importance, as extent of binding increases, systematic uptake of drug decreases. This, in turn, bears directly on effectiveness medication will eventually have. In recent study, determinations were made of binding percentages characteristic of 5 widely used antibiotics: Penicillin G(I), tetracycline (II), streptomycin (III), erthroomycin (IV), and chloramphenicol (V). Bovine serum was utilized in each instance, but results are comparable to what could be expected in human serum. Are true binding percentages for five antibiotics tested all equal? Let α = 0.05.
I
II
III
IV
V
29.6
27.3
5.8
21.6
24.3
32.6
6.8
17.4
28.5
30.8
11.0
18.3
32.0
34.8
8.3
19.0
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