Balance internal and external validity

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Question

A pragmatic approach is needed to balance internal and external validity, and generate evidence relevant to practice. The authors present strategies to promote such a balance, including using strict eligibility criteria, subgroup analysis, random assignment of patients based on preferences, a no-treatment control condition, and standardised and consistent implementation of the intervention. Conclusion: A balance between internal and external validity is essential to promote enrolment in the study and confidence in attributing its outcomes to an intervention, as well as to provide answers to clinically relevant questions such as who benefits most from which intervention. Implications for practice: The authors recommend researchers conduct a pilot study in advance of an evaluation, to help decide which strategies to use and how to balance internal and external validity.

Reference no: EM133778773

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