Reference no: EM13354084

1. Makers of generic drugs are required to demonstrate that their generic drug does not differ significantly from the "reference" drug it is intended to imitate. In an experiment to compare reference drugs to generic drugs, 30 subjects were given both a reference drug and the generic drug, with the order in which they received the drugs randomized. For all subjects, a washout period separated the two drugs so that the first drug had disappeared from the bloodstream before the second drug was given. The response was the difference in an absorption measure for the generic and the reference drug (generic measure - reference measure). None of the differences was equal to zero. The signed rank test is to be used to determine if the drugs differ significantly in absorption. If the responses have a continuous distribution that is not affected by the different treatments, W+ has mean
A. 465.0.
B. 232.5.
C. 48.6.

2. A researcher wishes to compare the effect of the rate of stepping on heart rate in a step-aerobics workout. A collection of 9 adult volunteers was randomly divided into three groups of 3 subjects each. Each group did a standard step-aerobics workout with group 1 at a low rate of stepping, group 2 at a medium rate of stepping, and group 3 at a high rate of stepping. The mean heart rate at the end of the workout for all subjects was determined in beats per minute. Assume the data for the three groups are independent. The observations are given below.

Group 1 95.7 92.6 102.6
Group 2 102.3 99.4 105.4
Group 3 107.3 125.4 119.2

The

A. sum of ranks for the three groups are R1 = 8, R2= 13, and R3 = 24.
B. value of the Kruskal-Wallis statistic is H = 5.96.
C. Both choices are correct