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What is the parasite that causes toxoplasmosis? How is the disease transmitted and what are its typical manifestations?
Toxoplasmosis is caused by the protozoan Toxoplasma gondii, a sporozoan.
Toxoplasmosis is a disease transmitted by cats, which are the definitive hosts of the parasite. Cats eliminate toxoplasma oocysts in feces; the oocysts are extremely resistant and remain viable for months in the environment. Human beings are infected when ingesting water or food contaminated by oocysts or when making contact with contaminated objects. Humans can also become infected by eating meat of animals like pork, cow and sheep, which can be intermediate hosts too. Vertical transmission, from mother to offspring, may also happen.
In toxoplasmosis the cystic form of the parasite invades tissues of the body, including the brain and the retina. The infestation is potentially fatal. In congenital toxoplasmosis the child might be present blindness and mental retardation.
Changes those are associated with programmed cell death, containing release of apoptotic bodies, blebbing, and nuclear fragmentation.
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It is conversion of antibody class to another resulting from genetic rearrangement of heavy chain same region genes in B cells. Isotope switching is also known as class switching.
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