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Contact Osteogenesis
In this the osteogenic cells attach to the implant surface and the new (de novo) bone is formed on the implant surface first. The developing bone matrix can directly interlock within the surface morphology. Since, by definition, no bone is present on the surface of the implant upon implantation, the implant surface has to become colonized by bone cells before bone matrix formation can begin. Optimization of contact osteogenesis can be done by implant design to ensure early stability (Primary stability) and a surface conducive to the attachment of the osteoblasts.
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KREB CYCLE
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