Tumor suppressor genes, Biology

Tumor Suppressor Genes

Tumor suppressor genes or anti-oncogenes generally inhibit cell division in cooperation with proto-oncogenes. The very existence of these genes prevents cells from undergoing neoplastic transformation. While tumor suppressor genes are inactivated by mutations or are deleted, the absence of their protein products permits malignant growth to occur. The most extensively studied disease caused through suppressor genes is the childhood tumor retinoblastoma (cancer of the retina). The gene included is Rb and the genotype of normal individuals is Rb/Rb. A prerequisite of tumor creation is the development of homozygosity or heterozygosity of the rb allele. The possible genetypes for retinoblastoma are, hence, rb/rb; rb/- or -/-

Posted Date: 1/31/2013 7:50:01 AM | Location : United States







Related Discussions:- Tumor suppressor genes, Assignment Help, Ask Question on Tumor suppressor genes, Get Answer, Expert's Help, Tumor suppressor genes Discussions

Write discussion on Tumor suppressor genes
Your posts are moderated
Related Questions
Q. What is prophylaxis? The Prophylaxis is measures taken to prevent diseases. For instance, the use of condoms in sexual relations is a prophylaxis against contamination by ag

The genetic code is the group of rules by that information encoded within genetic material DNA or mRNA sequences is changed into proteins (amino acid sequences) by living cells. Th

Which of the following is composed of ONLY glucose monomers? (mark all that apply) Select one or more: a. Starch b. glycogen c. Maltose d. chitin e. Cellulose


What are the types of brain?

Explain Polio Adults who have not previously been immunized against polio should receive a primary series of inactivated polio vaccine (IPV) if traveling to areas where polio i

Qualitative Changes The qualitative changes in the structure of proteins in response to stress can lead to the following: Resistance against denaturation of prote

DIGESTION OF FOOD MATERIALS Digestion, you know, involves  the mixing of  food, its movement through the digestive tract and chemical breakdown of the large ntolecules of  food

how many phylum does kingdom protista has?

Nitrogen is very important constituents of all organisms life  because it forms the structural parth of proteins, nucleic acids and chlorophyll molecules.               Earth 's