Renal failure and transplantation, Biology


Partial or total inability of kidney to carry excretory functions is called RF.

It leads to uremia (excess of urea in blood), salt-water imbalance stop secretion of erythropoietin.

Causes - Tubular injury, infection, bacterial toxins, glomerulonephritis, arterial or venous obstructions, int. precipitation of caclcium & urates, drug reaction, haemorrhage etc.


Grafting of kidney from a proper donor.

First kidney tranplant in world was performed between identical twins in 1954 by Dr Charles Hufnogel.

A living donor is used, if not available then cardiveric donor (cordover is a dead body) is used pretransplant prepartation. It includes haemodialysis to ensure normal metabolic state.


A kidney donor should be free of hypertension, diabetes & melignancy.

Cardaveric kidney is obtained from brain death person. Kidney are removed as early as possible, flushed with special cooling solutions such as mannitol & stored in iced solution. Preserved kidney usually fucntion normaly if transplanted within 48 hrs.

Posted Date: 10/2/2012 5:19:22 AM | Location : United States

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