Reciprocal translocation and fusion, Biology

In chronic myelogenous leukemia, white blood cells proliferate ceaselessly. In affected white blood cells, the BCR-ABL oncogene, the result of a gene fusion, transmits a constitutive growth signal. The severity of the disease correlates with the fraction of white blood cells that carry the BCR-ABL oncogene.

a) How does reciprocal translocation and fusion of the BCR and ABL genes lead to unregulated cell dIvision and leukemia

One treatment for the chronic myelogenous leukemia is a drug that inhibits the BCR-ABL protein and prevents it from transmitting the growth signal. This can result in remission of the disease by preventing proliferation of the cancer cells. During treatment of the disease, the effectiveness of treatment is monitored by assessing the level of the BCR-ABL oncogene present in a fixed quantity of white blood cells. Suppose that the structure of the DNA in the nonmutant BCR and ABL genes are as shown here, and that of the BCR-ABL oncogene is as depicted.

Short oligonucleotide primers that bind to the BCR and ABL genes as shown (the 3' end of each primers is at the tip of the arrow) are labeled 1, 2, 3, and 4.

553_Reciprocal translocation and fusion.png

b) How would you detect the presence of the BCR-ABL oncogene ?

c) If the drug is working, what would you expect to see ?

Posted Date: 2/18/2013 2:40:40 AM | Location : United States







Related Discussions:- Reciprocal translocation and fusion, Assignment Help, Ask Question on Reciprocal translocation and fusion, Get Answer, Expert's Help, Reciprocal translocation and fusion Discussions

Write discussion on Reciprocal translocation and fusion
Your posts are moderated
Related Questions
Modalities Available for Sterilization The most accepted methods of sterilization can be classified as follows: Physical Agents: These comprise of: Sunlight Drying

Q. What are the major cellular features of the beings of the plant kingdom? The typical plant cells are eukaryotic (have nucleus), photosynthetic (use light to make food) and a

Q. What are the major cells of the connective tissue proper? What is the name given to the intercellular material that surrounds these cells? The major cells of the connective


What are cell movements? How are these movements created? Cell movements are movements done by cell structures, like the movements of cilia and flagella, the pseudopod movement

A fatty acid having of a hydrocarbon chain and a terminal carboxylic acid group that is shown in the figure.  Most  fatty  acids  are  in  biology  have  an  even  number  of carbo

Psychology : This is the study of human mind. On other words Psychology is the science of behavior or mental processes. Its immediate aim is to understand the individuals or groups

Why is a leguminous crop rotation used in agriculture? Leguminous crop rotation and other crop rotations are used in agriculture because in these plants many bacteria significa

Zygotic or Suspensor Polyembryony Cleavage of the apical cells of the globular or filamentous proembryo produced by the zygote may result in two or more embryos in a seed. Th

What is Simple Transposition in Neonates ? A baby with this malformation needs to be operated without delay. A very cyanosed infant will require palliation by balloon arteries