Malignant catarrhal fever (mcf), Biology

Malignant catarrhal fever (MCF)


Malignant catarrhal fever is invariably fatal generalized lymphoproliferative disease of cattle and sometimes of wild ruminants. It is common in Africa, parts of Europe and in feedlot cattle in North America. The disease primarily affects lymphoid tissues and epithelial cells of respiratory and gastrointestinal tract. Sheep act as reservoir for MCF virus.


Epidemiology: The disease primarily affects adult cattle. Sheep act as carriers of the virus. The aetiological agent, a member of the sub-family Gammaherpesvirinae, is designated as Alcelaphine herpes virus-1. Cattle are believed to be infected via the relatively large amounts of virus present in the nasal secretions of wild beast calves. The virus is not transmitted between cattle, which appear to be dead end hosts.


Symptoms: The disease is characterized by high fever with copious discharge from the mouth, nose and eyes. Ulcers covered with necrotic tissue deposits are seen on the tongue, gums, inside of the cheek and certain other parts. Vesicles appear all over the body, and the face and head are swollen. Usually the animals die in about a week.


Diagnosis:
The disease is diagnosed by the absence of diarrhoea and the presence of copious discharges from the nose and eyes, and by absence of ulcers in the abomasum and intestines of dead animals, though it can create confusion with rinderpest. The virus can be isolated when washed peripheral blood leukocytes are inoculated in calf thyroid cells. Cell free inocula do not yield virus. The cytopathic changes require at least 3 days to appear and several passages in cell culture are often necessary. They are characterized by syncytia formation and by the presence of typical herpesvirus intranuclear inclusion bodies.Treatment, prevention and control: Symptomatic treatment helps in the natural process of recovery. At present, no effective vaccine is available for the prevention of the disease. Cattle serve as dead end hosts and susceptible animals pick up the infection from wild bovidae especially from nasal secretions of infected wild beast calves. Attempt to develop a vaccine have been unsuccessful so far.

Posted Date: 9/18/2012 6:38:49 AM | Location : United States







Related Discussions:- Malignant catarrhal fever (mcf), Assignment Help, Ask Question on Malignant catarrhal fever (mcf), Get Answer, Expert's Help, Malignant catarrhal fever (mcf) Discussions

Write discussion on Malignant catarrhal fever (mcf)
Your posts are moderated
Related Questions

prove oxygen is produced during photosynthesis in the presence of light

Celia is a nurse in a geriatric ward.  She noticed that older persons in her care are having problems sleeping at night.  She decided to introduce non-pharmocologic ways of relaxat

An A=T mispairing leads to an A=C substitution. The other DNA helix will contain a(n) __ pair. a. A=C b. A=T c. G=C d. B=Q e. T=T Can you also explain it please so if I'm ask

Bacteria, mutations, recombination, evolution, and adaption, how are all these related; must be written in two sentences.

Explain about the IMViC Test? IMViC test is a combination of four tests: (1) Indole production (2) Methyl Red test (3) Voges Proskauer, and (4) Citrate Utilization

Explain the Maltose and Cellobiose? Maltose consists of two a-D-glucose molecules with the alpha bond at carbon 1 of one molecule attached to the oxygen at carbon 4 of the se

Determine the type of bandage The most common type of bandage is the gauze bandage, a simple woven strip of material which comes in different widths and lengths.

Q. Show the parameters which are of interest in CHD? Total Cholesterol: Serum totnl cholesterol equals the sum of HDL-cholesterol (HDL-c), VLDL-cholesterol (VLDL-c) and LDL-cho

Pachytene: The pairing of homologous chromosomes is completed. Chromosomes become more and more thick. Each bivalent has four chromatids , which wrap around each o