Human gene responsible for a form of muscular dystrophy, Biology

Graduate student Dee Innay works in a human genome lab, whose goal is to identify the human gene responsible for a form of muscular dystrophy (MD).  Dee has mapped the MD gene to a narrow interval of chromosome 9.  The DNA sequence from that interval contains 6 ORFs. 

The lab works with 4 different extended families in which MD is segregating and has genomic DNA samples from 35 family members that are either affected, unaffected carriers, or unaffected non-carriers.  How would Dee figure out which ORF corresponds to the MD gene?  (Working in humans, she cannot perform transformation rescue or use a test that relies on gene function or rescue of the mutant phenotype.)

Posted Date: 2/27/2013 6:13:08 AM | Location : United States







Related Discussions:- Human gene responsible for a form of muscular dystrophy, Assignment Help, Ask Question on Human gene responsible for a form of muscular dystrophy, Get Answer, Expert's Help, Human gene responsible for a form of muscular dystrophy Discussions

Write discussion on Human gene responsible for a form of muscular dystrophy
Your posts are moderated
Related Questions
What is Conventional breeding Conventional breeding is a process in which genes for pesticidal traits are introduced into a plant by natural methods, such as cross-pollination

How Lysosomal enzymes involved in the scavenging of aged Lysosomal enzymes are also involved in the scavenging of aged and damaged cells. In several diseased states and also by

Define Prevalence of Weight Management? WHO (1998) estimates that in developing countries about 245 million adults are moderately underweight and 93 million severely underweigh

Explain the Digestion of carbohydrates? You are aware that 60-70% of energy is supplied by the dietary carbohydrates which are primarily present as polysaccharides (starch) fol

Respiration - Metabolism of Pollen Tubes In the unpollinated pistils of Hippeastrum hybridum very high O 2 , tension exists from stigma down through most of the style. During

Do fishes there an open or closed circulatory system? How many chambers does a fish heart have? How does blood flow all through the fish body? As in every vertebrate the circul

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4 How Yersinia enterol

Q. Explain Brachial or Radial Approach ? This technique involves performing the coronary angiogram through the right brachial artery in the right ante-cubital fossa. Usually a

Explain the Diarrhoeal Management Strategies? The diarrhoeal management strategies have had a major impact on less than 5 mortality rate. The distribution of ORS packets and ne

Determine energy expenditure for Climbers? The energy expenditure of 3250 Kcal/ day is reported in climbers to Mt. Everest using doubly labeled water teaching. Out of this, 161