Explain the bioavailability of folate, Biology

Explain the Bioavailability of Folate?

Bioavailability of folate from naturally occurring food sources is variable and frequently incomplete, as mentioned earlier in the food sources section. The bioavailability of natural folates is affected by the removal of the polyglutamate chain by the intestinal conjugase. This process is apparently not complete, thereby reducing the bioavailability of natural folates by as much as 25-5096. In contrast, synthetic folic acid appears to be highly bio available- 85% or greater. The low bioavailability and, more importantly, the poor chemical stability of the natural folates have a profound influence on the development of nutrient recommendations. This is particularly true if some of the dietary intake is as stable and bio available as the synthetic fonn, folic acid. Fortification of foods such as breakfast cereals and flour can add significant amounts of folic acid to the diet.

Since folic acid (synthetic) taken with food is 85% bio available but food folate is only about 50% bio available, folic acid taken with food is 85150 (i.e. 1.7) times more  available. Thus, if a mixture of synthetic folic acid plus food folate bas been fed, dietary folate equivalents (DFEs) are calculated as follows to determine the EAR:

yg of DFE provided = [mg of food folate + (1.7 x mg of synthetic folic acid)].

To be comparable to food folate, only half as much folic acid is needed if taken on an empty stomach, i.e. lpg of DFE: = lmg of food folate = 0.5 mg of folic acid taken on an empty stomach = 0.6 mg of folic acid with meals.

Alcohol interferes with the absorption of folate and increases excretion of folate by the kidney.

Posted Date: 6/29/2013 3:44:04 AM | Location : United States

Related Discussions:- Explain the bioavailability of folate, Assignment Help, Ask Question on Explain the bioavailability of folate, Get Answer, Expert's Help, Explain the bioavailability of folate Discussions

Write discussion on Explain the bioavailability of folate
Your posts are moderated
Related Questions
Define Methods of Estimation of Energy Expenditure and Requirements? There are a variety of methods available to measure human energy expenditure. Knowledge of these methods wi

Atom has how many eletrons

Describe the common operations performed in paediatric cardiac surgery 1) Closed Heart Surgery: Surgery on Heart or Great Vessels done without using the Heart-Lung machine.

Estimate Daily energy requirement and safe protein intake? The estimated mean daily per capita energy requirement of 2070 Kcal rounded up  to 2100 Kcal is based on WHO technica

compare the lengths and paths of the uterine tubes (oviducts) of the cat and the human

Assessment This includes the data collection (nursing history and physical assessment), comparison of data with the normal, and analysis of the data gathered. Systematic an

What is aneuploidy? What are the conditions caused by the aneuploidies? The Aneuploidy is an abnormal number of chromosomes in the cells of an individual. The major aneuploi

What proportion of children with down syndrome do you expect when women with down syndrome have children with men who have 46 chromosomes? justify answer

Major Criteria 1) Positive blood culture • Typical microorganism for infective endocarditis from two separate blood cultures Viridans streptococci, Streptococcus bovis, HAC

The tertiary protein structure is a spatial conformation additional to the secondary structure in which the alpha helix or the beta-sheet folds up itself. The forces that stay the