Describe the basic mechanisms in plaque formation, Biology

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.

Posted Date: 5/10/2013 3:15:03 AM | Location : United States







Related Discussions:- Describe the basic mechanisms in plaque formation, Assignment Help, Ask Question on Describe the basic mechanisms in plaque formation, Get Answer, Expert's Help, Describe the basic mechanisms in plaque formation Discussions

Write discussion on Describe the basic mechanisms in plaque formation
Your posts are moderated
Related Questions
What is Soil Horizons   In a profile, different horizons or layers are identified by certain designations assigned after comparison of the properties of the layer with those o

Define briefly about the Seed Proteins? Although a large number of plants produce seeds having protein contents in excess of 15%, only a few are utilized for food, eg. soybean,

Explain the Selective Media - Culture Media? It is used to select specific groups of bacteria by favouring the growth of desired bacteria and inhibiting the growth of undesired

Which part of the carbon cycle is responsible for the enhancing concentration of carbon dioxide in the atmosphere. The burning of fossilized products (coal and oil) of some pla

How does the excretory system of nematodes work? The metabolic residuals of nematodes are collected by two longitudinal lateral excretory channels that open in one excretory po

Why the orange trees are often sprayed with water? Although it is grossly counter-intuitive, whenever citrus groves are in risk of experiencing below-freezing temperatures, the

Periodicity (Phenology, Aspection) It refers to the study of seasonal changes in the community, that is, the periodic phenomena of organisms in relation to their climate. Peri

Define Requirements of Carbohydrates during Surgery? Carbohydrates: Carbohydrates are needed to build up glycogen stores and spare the proteins for tissue synthesis, Around GO%

Explain the term Brown-Sequard Syndrome Brown-Sequard syndrome is a rare spinal disorder that results from an injury to one side of the spinal cord in which the spinal cord is

Determine the maximum crop yield In determining maximum crop yield it was thought that a given plant let us say corn, is only inherently capable of producing a given amount of