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Blood clotting, Biology
D CLOTTING -
It is a nature's device to check the excessive loss of blood from an injury.
Bleeding time is 1-3 minutes. Clotting time is 2-6 minutes.
Process of clotting is initiated by platelets / Thrombocytes.
After clotting remaining part is serum. Clotting is a bio-chemical reaction, explained by Hobel.
Clotting theory is given by cascode. Vit. K is necessory for clotting.
In haemophillia (sex-linked inheritance) VIII factor is absent so injection of AHG (Anti haemophilic globulin) are given.
At the point of injury serotonine & thromboplastin (lipoprotein) are released.
Serotonine is helpful in vaso constriction. Thromboplastin helps in the formation of prothrombinase.
In presence of prothrombinase prothrombin is converted into thrombin.
Thrombin reacts with fibrinogen in presence of air & Ca++ to form fibrin. Network of fibrin forms clot.
In presence of XII factor (Hagmen factor / glycoprotein) danse net is formed.
Posted Date: 10/2/2012 3:06:00 AM | Location : United States
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