Anticoagulants, Biology

ANTICOAGULANTS

(a) Heparin (hepar = liver) . It is synthesized by mast cells of connective tissue and liver cells. It is a heteropolysaccharide. It increases the effectivity of antithrombin III (a - globulin) which inactivates the thrombin so prevents conversion of fibrinogen into fibrin.

(b) Hirudin. It is an anticoagulant present in the saliva of salivary glands of leech and is mixed with blood of host during its storage in its crop.

(c) Warfarin. It is an anticoagulant of plant origin, which when given to a patient, lowers the formation of prothrombin and factors VII, IX and X from liver cells by lowering the activity of Vitamin K.

(d) Sodium oxalate, sodium citrate and EDT A (Ethylene diamine tetra acetic acid) are used as anticoagulants in blood banks as these bind Ca++, so these are called chelating agents. .

(e) Chilling of blood also delays blood clotting as it lowers the activity of enzymes involved in blood clotting.

 

ROLE OF VITAMIN-K IN BLOOD CLOTTING -

Vitamin K, also called anti-haemorrhagic factor, is a fat soluble vitamin and is essential for the formation of prothrombin from the liver. Deficiency of vitamin K causes hypoprothrombinemia which interferes with blood clotting. Vitamin K is also synthesized by intestinal bacteria.

Posted Date: 10/1/2012 3:34:46 AM | Location : United States







Related Discussions:- Anticoagulants, Assignment Help, Ask Question on Anticoagulants, Get Answer, Expert's Help, Anticoagulants Discussions

Write discussion on Anticoagulants
Your posts are moderated
Related Questions
What are the final energetic products of each round of the Krebs cycle? Where is most part of the utile energy at the end of Krebs cycle found? After each round of the Krebs cy

Micrographia is abnormally small, cramped handwriting and/or the progression to continually smaller handwriting. This is one of the symptoms of Parkinson''s disease.

What do you mean by branchial basket? In ascidian adults the pharynx is enlarged to form branchial basket. Pharyngeal openings in wall of the basket allow water to pass through

Responses Of Plants To Stress The internal chemical signals and environmental factors - the external signals which are perceived by special molecules present in the cell. In t

Removal of obturating material -Gutta percha . -Carrier  bassed gutta perca. -silver points . - paste type. - obstructed fracture instrument .

EPITHELIA L TISSUE OR EPITHELIA Epithelium term coined by Ruysh, it was applied originally to thin skin covering the nipple. (G.epi = upon, thele = nipple) Epithelial tis

Define about the Carbohydrates? In the previous unit, we came to know that availability of glucose is the major factor in exercise performance. Hence, carbohydrate manipulation

How many carbon dioxide molecules are liberated after each cycle of the Krebs cycle? For a single glucose how many carbon dioxide molecules were already liberated by the aerobic re

Treatment of latent tb infection The risk of developing clinical tuberculosis is greatest in patients with latent TB who are also infected with HIV or are receiving immunosuppr

Who is the founder of theory survival of the fittest ?