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A genetic mutation occurs that alters the specificity of the Golgi enzyme that phosphorylates mannose residues in theoligosaccharides of glycoproteins. The effect of the mutation issuch that the enzyme now indiscriminately and randomlyphosphorylates mannose residues on all glycoproteins passingthrough the Golgi complex.
A. What is the normal role of this enzyme?
B. What is the normal destination of Golgi contents that are phosphorylated on mannoseresidues and how do they get there?
C. What are the consequences of this mutation?
The UV absorption in proteins at 280 nm is largely due to tryptophan residues. The molar extinction coefficient of tryptophan is 5380 M-1cm-1. Exactly 0.25 g of a protein is dissolved in 200 milliliters of a neutral buffer.
Assume that a disease is inherited via a dominant mode of inheritance and that one of the parents is affected with the disease and the other is not.
What is the potential weight gain that could result just from stopping that activity for 10 months? Enter your answer to one decimal place, which may include a zero, e.g. 4.0. Choose the appropriate units using the drop-down list. energy cost of p..
Cystic fibrosis is a chronic lung and digestive disease caused through a mutation in the CFTR gene on chromosome 7. In the US approximately 39 in 10,000 individuals are affected.
What experiment could be performed to ascertain if an antimicrobial agent is bactericidal or bacteriostatic? Can a bacteriostatic agent become bactericidal in the long run or vice versa? Why?
Show (using both graphs and words) how the equilibrium theory of island biogeography could used to support the conclusion (despite the apparent contradiction). In addition include two other plausible explanations for this pattern.
If you were to remove the ER retrieval signal (KDEL) from protein disulfide isomerase (PDI), which is normally a soluble resident of the ER lumen, where would you expect the modified PDI to be located?
A pea plant with yellow seeds was crossed with a plant with green seeds. The F1 generation produced plants with yellow seeds. Explain why green seeds reappeared in the F2 generation.
Discuss how insertion, deletion, and base substitution of nucleotides can have a significant impact on genes. Find three specific examples of ways in which a very small change in DNA
describe the first step involved in replication of each genome. Your description can include a diagram and should cover.
What is the genetic material of a virus?
One gene encodes the second enzyme in a melanin-synthesizing pathway. An individual who is homozygous for a recessive allele of this gene cannot make or deposit melanin in body tissues.
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